Transcriptional upregulation of p19INK4d upon diverse genotoxic stress is critical for optimal DNA damage response.
about
E2F1 induces p19INK4d, a protein involved in the DNA damage response, following UV irradiationRole of p19ink4d in the pathogenesis of hearing loss.E2F1-mediated upregulation of p19INK4d determines its periodic expression during cell cycle and regulates cellular proliferation.CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage responseChromatin relaxation-mediated induction of p19INK4d increases the ability of cells to repair damaged DNA.p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging.p19(INK4d) mRNA and protein expression as new prognostic factors in ovarian cancer patients.E2F1 and E2F2 induction in response to DNA damage preserves genomic stability in neuronal cells.Nuclear translocation of p19INK4d in response to oxidative DNA damage promotes chromatin relaxation.
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Transcriptional upregulation of p19INK4d upon diverse genotoxic stress is critical for optimal DNA damage response.
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2008 nî lūn-bûn
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Transcriptional upregulation o ...... r optimal DNA damage response.
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Transcriptional upregulation o ...... r optimal DNA damage response.
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Transcriptional upregulation o ...... r optimal DNA damage response.
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Transcriptional upregulation o ...... r optimal DNA damage response.
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Transcriptional upregulation o ...... r optimal DNA damage response.
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Transcriptional upregulation o ...... r optimal DNA damage response.
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Transcriptional upregulation o ...... or optimal DNA damage response
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Abel C Carcagno
Julieta M Ceruti
Mariela C Marazita
María E Scassa
Pablo F Sirkin
P304
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10.1016/J.BIOCEL.2008.12.005
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2008-12-14T00:00:00Z