Fluorescence resonance energy transfer analysis of alpha 2a-adrenergic receptor activation reveals distinct agonist-specific conformational changes.
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Chemogenomic analysis of G-protein coupled receptors and their ligands deciphers locks and keys governing diverse aspects of signallingFluorescence dequenching makes haem-free soluble guanylate cyclase detectable in living cellsInvestigation of D₂ receptor-agonist interactions using a combination of pharmacophore and receptor homology modeling.Principles and determinants of G-protein coupling by the rhodopsin-like thyrotropin receptor.Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.FRET-based detection of M1 muscarinic acetylcholine receptor activation by orthosteric and allosteric agonists.The potential for selective pharmacological therapies through biased receptor signalingExploring a role for heteromerization in GPCR signalling specificity.Activity of Bradykinin B2 Receptor Is Regulated by Long-Chain Polyunsaturated Fatty Acids.Fluorescent labeling of tetracysteine-tagged proteins in intact cellsGenetically encodable fluorescent biosensors for tracking signaling dynamics in living cells.Active-state model of a dopamine D2 receptor-Gαi complex stabilized by aripiprazole-type partial agonists.Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy.Advances in receptor conformation research: the quest for functionally selective conformations focusing on the β2-adrenoceptorMolecular determinants of A2AR-D2R allosterism: role of the intracellular loop 3 of the D2R.Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptorsAn Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory.Green light to illuminate signal transduction events.Minireview: More than just a hammer: ligand "bias" and pharmaceutical discovery.On the expanding terminology in the GPCR field: the meaning of receptor mosaics and receptor heteromers.Exploration of biarsenical chemistry--challenges in protein research.G protein-mediated stretch reception.New concepts in pharmacological efficacy at 7TM receptors: IUPHAR review 2.How ligands and signalling proteins affect G-protein-coupled receptors' conformational landscape.Sequential inter- and intrasubunit rearrangements during activation of dimeric metabotropic glutamate receptor 1.The ins and outs of adrenergic signaling.Optical probes based on G protein-coupled receptors - added work or added value?Conformational Profiling of the AT1 Angiotensin II Receptor Reflects Biased Agonism, G Protein Coupling, and Cellular Context.Recent developments of genetically encoded optical sensors for cell biology.Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL).A fluorescence resonance energy transfer-based M2 muscarinic receptor sensor reveals rapid kinetics of allosteric modulation.Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogeneous time-resolved FRETThe mode of agonist binding to a G protein-coupled receptor switches the effect that voltage changes have on signaling.From molecular details of the interplay between transmembrane helices of the thyrotropin receptor to general aspects of signal transduction in family a G-protein-coupled receptors (GPCRs).Investigation of D₁ receptor-agonist interactions and D₁/D₂ agonist selectivity using a combination of pharmacophore and receptor homology modeling.Rotational diffusion of the α(2a) adrenergic receptor revealed by FlAsH labeling in living cells.Interaction of morphine but not fentanyl with cerebral alpha2-adrenoceptors in alpha2-adrenoceptor knockout mice.A kinetic model of GPCRs: analysis of G protein activity, occupancy, coupling and receptor-state affinity constants.Conformational biosensors reveal allosteric interactions between heterodimeric AT1 angiotensin and prostaglandin F2α receptors.Dynamic ligand binding dictates partial agonism at a G protein-coupled receptor.
P2860
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P2860
Fluorescence resonance energy transfer analysis of alpha 2a-adrenergic receptor activation reveals distinct agonist-specific conformational changes.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Fluorescence resonance energy ...... ecific conformational changes.
@en
Fluorescence resonance energy ...... ecific conformational changes.
@nl
type
label
Fluorescence resonance energy ...... ecific conformational changes.
@en
Fluorescence resonance energy ...... ecific conformational changes.
@nl
prefLabel
Fluorescence resonance energy ...... ecific conformational changes.
@en
Fluorescence resonance energy ...... ecific conformational changes.
@nl
P2093
P356
P1476
Fluorescence resonance energy ...... pecific conformational changes
@en
P2093
P304
P356
10.1124/MOL.108.052399
P577
2008-12-23T00:00:00Z