Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination. - Wikidata - wikimedia - TriplyDB

Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination.

Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination.

http://www.wikidata.org/entity/Q39940519

about

Distinct roles of MK2 and MK5 in cAMP/PKA- and stress/p38MAPK-induced heat shock protein 27 phosphorylation Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases MAPK-Activated Protein Kinases (MKs): Novel Insights and Challenges The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway Comparative Analysis of Two Gene-Targeting Approaches Challenges the Tumor-Suppressive Role of the Protein Kinase MK5/PRAK The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor Scaffolding by ERK3 regulates MK5 in development Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5 Physiological roles of mitogen-activated-protein-kinase-activated p38-regulated/activated protein kinase ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions Microwave-assisted synthesis of a pyrazolyl ketone library for evaluation as p38 MAPK inhibitors in Werner syndrome cells.Targeted inactivation of Mapk4 in mice reveals specific nonredundant functions of Erk3/Erk4 subfamily mitogen-activated protein kinases.Nijmegen breakage syndrome fibroblasts expressing the C-terminal truncated NBN(p70) protein undergo p38/MK2-dependent premature senescence.Transgenic mice expressing constitutive active MAPKAPK5 display gender-dependent differences in exploration and activity.Characterization of hsp27 kinases activated by elevated aortic pressure in heart.The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB.c-Jun controls histone modifications, NF-kappaB recruitment, and RNA polymerase II function to activate the ccl2 gene.p38 pathway kinases as anti-inflammatory drug targets.Comprehensive characterization of heat shock protein 27 phosphorylation in human endothelial cells stimulated by the microbial dithiole thiolutin Characterization of a novel MK3 splice variant from murine ventricular myocardium.Comparative molecular dynamics simulations of mitogen-activated protein kinase-activated protein kinase 5.Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update.Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5 Mechanisms of the joint-protective effects of p38 MAPK inhibitors in rodent arthritis.Use of p38 MAPK Inhibitors for the Treatment of Werner Syndrome.MK5 activates Rag transcription via Foxo1 in developing B cells.Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors.Synthesis of the highly selective p38 MAPK inhibitor UR-13756 for possible therapeutic use in Werner syndrome.Characterization of the expression and regulation of MK5 in the murine ventricular myocardium.Gram-scale synthesis of the p38α MAPK-inhibitor VX-745 for preclinical studies into Werner syndrome.The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation.Small molecule inhibition of p38 MAP kinase extends the replicative life span of human ATR-Seckel syndrome fibroblasts.Serine residue 115 of MAPK-activated protein kinase MK5 is crucial for its PKA-regulated nuclear export and biological function.Septin 8 is an interaction partner and in vitro substrate of MK5.Modulation of F-actin rearrangement by the cyclic AMP/cAMP-dependent protein kinase (PKA) pathway is mediated by MAPK-activated protein kinase 5 and requires PKA-induced nuclear export of MK5.MK5: A novel regulator of cardiac fibroblast function?MK5 haplodeficiency attenuates hypertrophy and preserves diastolic function during remodeling induced by chronic pressure overload in the mouse heart.Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4.Analysis of properties of small heat shock protein Hsp25 in MAPK-activated protein kinase 2 (MK2)-deficient cells: MK2-dependent insolubilization of Hsp25 oligomers correlates with susceptibility to stress.

P2860

Q24302534-B304202D-18D4-48FC-8B6E-A22A99A57519 Q24632768-9A4D0062-FF0A-40DA-9688-0728E6C2C754 Q26771339-6AB93575-D8C4-4980-9D2B-C0BA0983A2EF Q28504513-86CAF6F4-6233-4ED4-853B-83AD3C59E503 Q28508397-4B5DBF26-A74A-4563-AFD4-2C8CBF9CDFD7 Q28547394-A4E18347-53D5-41FF-87EE-478B9F9994A8 Q28587209-B8E03293-4451-45D5-8A34-D35F58A1E623 Q28587317-24D8B9E1-8C3A-447C-89A0-23BA7606A926 Q28592542-121D9123-48A9-469E-A8CA-586F8E488315 Q28743846-105962BA-BED2-4AD0-B639-F2EC374D5511 Q29615216-4F3209C4-5EE0-4084-B86A-A3F4669EC0E9 Q33852488-51381B3F-6231-4221-BD7B-E266C9D749CF Q34416268-3C54BBBF-EA78-4944-B3D2-B4EC2DC5E110 Q35008261-8E1BFAA7-C36C-4B4F-8A65-178C95F0A4A3 Q36453803-18147609-D597-4CD0-9DFC-5C17D1294387 Q36544841-01CA33F7-AF8B-42B3-A058-B654A50376E9 Q36668758-799A5F22-FBD8-44E7-9DDB-49D0B01BF94B Q36748131-3DACD5DD-79E5-489B-8EF3-569585CA2F65 Q36919718-33B2E739-0D37-449B-92A3-5C6A6005FAAB Q37135801-E4C4DA77-D2E1-40BA-A5E8-462289DE52C0 Q37634351-874EE6C3-FA83-4FDF-BCF4-8B5B657DB3E4 Q37684120-846D688D-5E41-47C1-8B00-B4D81C7BEA71 Q38005668-55E0FA17-81AE-4A6C-8BCA-471586FD717D Q38026611-EE70B002-3E5B-47DE-B158-6F9D2B176F3C Q38088305-0FDDB61C-0B3E-4F46-9288-B3433F8F08DE Q38974348-0017E57E-564D-4C80-848A-D5EBF927EB0B Q39121516-50E41549-F312-4519-97DA-8093C609AC14 Q39508065-048E9791-54E5-43B4-AD1C-F4C864FDD644 Q39572401-959B0173-3B2E-4531-8B36-5A0540EAC793 Q39730292-1C3BBC1F-88C6-478C-8685-B91D61FBE19A Q39769285-92C1181C-D71D-431C-863A-5A5E14FD3BE4 Q41887469-A8276DF5-9616-4CC1-A2E3-CA00DF5DE9BF Q41932634-61F6C903-0652-4B03-A231-3CD49C05A66C Q41932860-8846041B-6A44-4B12-9EA0-23F841298413 Q42180893-EEB80505-F10C-4493-8C0A-922A8D341902 Q45345894-79515317-1FEC-4789-A1B3-D79F7898E5A3 Q47755823-0DBEF466-DC87-4BE3-9DCC-5170C87EF61F Q48247128-9228427C-750E-4D13-A009-85E53053DB34 Q50337024-91C53408-69BC-4559-86C3-10713F646C0A Q50723369-28310003-61F3-492B-8205-D0E4E99AF8AD

P2860

Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination.

http://www.wikidata.org/entity/Q39940519

description

2003 nî lūn-bûn

@nan

2003年の論文

@ja

2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

2003年论文

@zh

2003年论文

@zh-cn

name

Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination.

@en

Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination.

@nl

type

label

Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination.

@en

Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination.

@nl

prefLabel

Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination.

@en

Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination.

@nl

P1433

Q39940519-5AE35AC1-BEB1-41C6-AAF0-868304C7F2D4

P1476

Q39940519-15CBF029-C6BE-4849-BECB-169E6DE59CC5

P2093

Q39940519-0D7A72B8-323C-4835-A0CC-D0120432F6A5

Q39940519-2CE0371D-B61D-46C0-808C-FDEE71610961

Q39940519-4EE1DF37-4CB4-4561-8002-36DD61B85974

Q39940519-6185F0C5-FEF4-4C34-8032-CF79318AB304

Q39940519-97107FB8-4319-451E-A585-B24514292B2D

Q39940519-DBF3D035-2FAB-482A-B03B-3321C7E1CDFE

Q39940519-DD74B43F-659E-4E49-B0E2-138C417B73BB

Q39940519-E89D50EC-02F5-454A-85A0-ECBA6762B33C

P2860

Q39940519-02E65BC0-5FDA-4110-8138-B818C0680D6B

Q39940519-04A8A5F6-1841-4EED-A3EC-9D622D020B84

Q39940519-0E957A66-A7B2-478C-B5FA-BE4524D9DB8B

Q39940519-36362CE9-4E98-49E5-8DD3-5FB7FD9FF4D0

Q39940519-3AA1C222-264C-4E4E-B3AD-EAC83362BA17

Q39940519-460DCC9F-7433-4E95-AF54-80053A176642

Q39940519-51D105FA-72BA-4AEC-8E1C-83385D5640C2

Q39940519-6A04D7DF-5343-4E7B-98F0-AD88017E9AC9

Q39940519-7818CEE0-3C3A-418A-A635-DB185D3DAB50

Q39940519-7C4C0CF8-2A51-43EF-8B5F-91ED6D73BF03

P304

Q39940519-ACEC68DB-2987-4DF1-8678-BF8E19E40EBA

P31

Q39940519-637A843B-2612-4244-94E6-26D4F6E52821

P356

Q39940519-1919631A-3EBB-4AF9-B3C8-9D5CB5AC9DDC

P407

Q39940519-212D580E-B1F1-41A2-842D-5E74E8864290

P433

Q39940519-AD0B2695-D48C-4A64-91E5-9DBEC0A2ED26

P478

Q39940519-C59EE37A-FA79-4B1C-8295-A34CE89B3FF3

P50

Q39940519-6E1235A3-A747-45DC-9B63-CE2D0DB3ED10

Q39940519-9FF2A099-5542-41FD-A196-866CEF8149A1

P577

Q39940519-DF8A2D76-FD35-4C85-984E-60BCF979AFF9

P698

Q39940519-3085E43C-6FA6-4A80-B433-544B95811223

P932

Q39940519-B66C9D7F-5F8A-4AD5-B51F-1229CA5C5EA3

P356

MCB.23.21.7732-7741.2003

P1433

Molecular and Cellular Biology

P1476

Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination.

@en

P2093

Achim D Gruber

http://www.w3.org/2001/XMLSchema#string

Anke Friedrich

http://www.w3.org/2001/XMLSchema#string

Elke Butt

http://www.w3.org/2001/XMLSchema#string

Hans-Dieter Volk

http://www.w3.org/2001/XMLSchema#string

Helmut E Meyer

http://www.w3.org/2001/XMLSchema#string

Kathrin Laabeta

http://www.w3.org/2001/XMLSchema#string

Katrin Marcus

http://www.w3.org/2001/XMLSchema#string

Yu Shi

http://www.w3.org/2001/XMLSchema#string

P2860

Cloning and characterization of RLPK, a novel RSK-related protein kinase

Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity

The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3

Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase

A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress

The protein kinase complement of the human genome

PRAK, a novel protein kinase regulated by the p38 MAP kinase

Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation

Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions.

ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents

P304

7732-7741

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1128/MCB.23.21.7732-7741.2003

http://www.w3.org/2001/XMLSchema#string

P407

P433

21

http://www.w3.org/2001/XMLSchema#string

P478

23

http://www.w3.org/2001/XMLSchema#string

P50

Matthias Gaestel

Alexey Kotlyarov

P577

2003-11-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

14560018

http://www.w3.org/2001/XMLSchema#string

P932

207624

http://www.w3.org/2001/XMLSchema#string