Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonist effects
about
Crystal structure of the ATP-gated P2X(4) ion channel in the closed stateInsights into the channel gating of P2X receptors from structures, dynamics and small moleculesInsights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide PolymorphismsAgonist antagonist interactions at the rapidly desensitizing P2X3 receptorActivation and regulation of purinergic P2X receptor channelsATP-P2X7 receptor signaling controls basal and TNFα-stimulated glial cell proliferation.Paroxetine suppresses recombinant human P2X7 responsesAllosteric modulation of ATP-gated P2X receptor channelsStructural basis for subtype-specific inhibition of the P2X7 receptor.Structural interpretation of P2X receptor mutagenesis studies on drug actionPositron emission tomography in amyotrophic lateral sclerosis: Towards targeting of molecular pathological hallmarks.Phe369(7.38) at human 5-HT(7) receptors confers interspecies selectivity to antagonists and partial agonists.Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors.Mechanism of action of species-selective P2X(7) receptor antagonists.Development of a comprehensive set of P2 receptor pharmacological research compoundsDocking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human.P2X receptor chimeras highlight roles of the amino terminus to partial agonist efficacy, the carboxyl terminus to recovery from desensitization, and independent regulation of channel transitionsThe P2X(7) receptor mediates the uptake of organic cations in canine erythrocytes and mononuclear leukocytes: comparison to equivalent human cell types.The P2X7 Receptor.A residue in the TRPM2 channel outer pore is crucial in determining species-dependent sensitivity to extracellular acidic pH
P2860
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P2860
Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonist effects
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Identification of regions of the P2X
@nl
Identification of regions of t ...... ferences in antagonist effects
@en
type
label
Identification of regions of the P2X
@nl
Identification of regions of t ...... ferences in antagonist effects
@en
prefLabel
Identification of regions of the P2X
@nl
Identification of regions of t ...... ferences in antagonist effects
@en
P2093
P2860
P356
P1476
Identification of regions of t ...... ferences in antagonist effects
@en
P2093
A D Michel
D Livermore
J Holbrook
J P Condreay
K Thompson
P2860
P304
P356
10.1038/BJP.2008.306
P407
P577
2008-07-28T00:00:00Z