Caspase-3 activation triggers extracellular cathepsin L release and endorepellin proteolysis.
about
Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonismEndorepellin laminin-like globular 1/2 domains bind Ig3-5 of vascular endothelial growth factor (VEGF) receptor 2 and block pro-angiogenic signaling by VEGFA in endothelial cellsThe role of perlecan and endorepellin in the control of tumor angiogenesis and endothelial cell autophagyDecoding the Matrix: Instructive Roles of Proteoglycan ReceptorsA fragment of the LG3 peptide of endorepellin is present in the urine of physically active mining workers: a potential marker of physical activityBlood vessel repair and regeneration in the ischaemic heartPerlecan Domain V induces VEGf secretion in brain endothelial cells through integrin α5β1 and ERK-dependent signaling pathways.LG3 fragment of endorepellin is a possible biomarker of severity in IgA nephropathy.Antiperlecan antibodies are novel accelerators of immune-mediated vascular injury.RNA-seq profiles of immune related genes in the staghorn coral Acropora cervicornis infected with white band diseaseImpact of ischemia-reperfusion on extracellular matrix processing and structure of the basement membrane of the heartNovel insights into the function and dynamics of extracellular matrix in liver fibrosis.Proteolytically Derived Endogenous Angioinhibitors Originating from the Extracellular MatrixCaspase activation regulates the extracellular export of autophagic vacuolesCathepsin L acutely alters microvessel integrity within the neurovascular unit during focal cerebral ischemia.Endorepellin affects angiogenesis by antagonizing diverse vascular endothelial growth factor receptor 2 (VEGFR2)-evoked signaling pathways: transcriptional repression of hypoxia-inducible factor 1α and VEGFA and concurrent inhibition of nuclear factMatrilysin/matrix metalloproteinase-7(MMP7) cleavage of perlecan/HSPG2 creates a molecular switch to alter prostate cancer cell behavior.Endostatin and endorepellin: A common route of action for similar angiostatic cancer avengersProteoglycans in cancer biology, tumour microenvironment and angiogenesis.Diverse cell signaling events modulated by perlecan.Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity.Endothelial Cells in Antibody-Mediated Rejection of Kidney Transplantation: Pathogenesis Mechanisms and Therapeutic Implications.Regulation of endothelial cell functions by basement membrane- and arachidonic acid-derived products.The molecular legacy of apoptosis in transplantation.Oxygen-glucose deprivation and interleukin-1α trigger the release of perlecan LG3 by cells of neurovascular unit.Molecular Functions of Glycoconjugates in Autophagy.The importance of non-HLA antibodies in transplantation.Mast cells produce novel shorter forms of perlecan that contain functional endorepellin: a role in angiogenesis and wound healing.Participation of haemocytes in fat body degradation via cathepsin L expression.Oxygen-glucose deprivation (OGD) and interleukin-1 (IL-1) differentially modulate cathepsin B/L mediated generation of neuroprotective perlecan LG3 by neurons.Autophagy fosters myofibroblast differentiation through MTORC2 activation and downstream upregulation of CTGF.MFG-E8 released by apoptotic endothelial cells triggers anti-inflammatory macrophage reprogramming.Caspase-3-dependent export of TCTP: a novel pathway for antiapoptotic intercellular communicationInteraction of 2-APB, dantrolene, and TDMT with IP3R and RyR modulates ER stress-induced programmed cell death I and II in neuron-like PC12 cells: an experimental and computational investigation.Perlecan Domain V Inhibits Amyloid-β Induced Activation of the α2β1 Integrin-Mediated Neurotoxic Signaling Cascade.HSPG2 (perlecan) is cleaved by BMP1; TLL1; TLL2; Cathepsin L1The perlecan fragment LG3 regulates homing of mesenchymal stem cells and neointima formation during vascular rejection.The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection.A comprehensive characterization of membrane vesicles released by autophagic human endothelial cells.
P2860
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P2860
Caspase-3 activation triggers extracellular cathepsin L release and endorepellin proteolysis.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Caspase-3 activation triggers ...... and endorepellin proteolysis.
@en
Caspase-3 activation triggers ...... and endorepellin proteolysis.
@nl
type
label
Caspase-3 activation triggers ...... and endorepellin proteolysis.
@en
Caspase-3 activation triggers ...... and endorepellin proteolysis.
@nl
prefLabel
Caspase-3 activation triggers ...... and endorepellin proteolysis.
@en
Caspase-3 activation triggers ...... and endorepellin proteolysis.
@nl
P2093
P2860
P356
P1476
Caspase-3 activation triggers ...... and endorepellin proteolysis.
@en
P2093
Alexandre Prat
Alexey V Pshezhetsky
Isabelle Sirois
Jean-François Cailhier
Marc-André Raymond
Nathalie Brassard
Patrick Laplante
Stéphanie Lepage
P2860
P304
27220-27229
P356
10.1074/JBC.M801164200
P407
P577
2008-07-24T00:00:00Z