Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.
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Update on the Kelch-like (KLHL) gene familyMolecular basis of electrophilic and oxidative defense: promises and perils of Nrf2NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activationCancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancyRedox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and TherapyMitochondria, cholesterol and cancer cell metabolismCullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic ImplicationsSquamous cell carcinomas of the lung and of the head and neck: new insights on molecular characterizationRedox Modulating NRF2: A Potential Mediator of Cancer Stem Cell ResistanceRedox Regulation in Cancer Stem CellsRoles nrf2 plays in myeloid cells and related disordersStructural Basis of Alternative DNA Recognition by Maf Transcription FactorsDrugging the addict: non-oncogene addiction as a target for cancer therapyDual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanismsGlycogen synthase kinase 3 regulates expression of nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) and inhibits pro-survival function of Nrf1Nrf2 is a potential prognostic marker and promotes proliferation and invasion in human hepatocellular carcinomaStress-activated cap'n'collar transcription factors in aging and human diseaseCACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agentsArsenic-mediated activation of the Nrf2-Keap1 antioxidant pathwayIntronic DNA elements regulate Nrf2 chemical responsiveness of the human microsomal epoxide hydrolase gene (EPHX1) through a far upstream alternative promoterProgress and prospects of reactive oxygen species in metal carcinogenesisThe complexity of the Nrf2 pathway: beyond the antioxidant responseNrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and ProgressionThe Keap1-Nrf2 system in cancers: stress response and anabolic metabolismp62 links autophagy and Nrf2 signalingNrf2 signaling and cell survivalMechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative diseaseTumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancerA new model for raf kinase inhibitory protein induced chemotherapeutic resistanceNrf2:INrf2 (Keap1) signaling in oxidative stressGenetic disruption of KEAP1/CUL3 E3 ubiquitin ligase complex components is a key mechanism of NF-kappaB pathway activation in lung cancer.Spotlite: web application and augmented algorithms for predicting co-complexed proteins from affinity purification--mass spectrometry data.Generation of a New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B1 Toxicity.NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation.The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel.WDR23 regulates NRF2 independently of KEAP1.Role of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene.Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains
P2860
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P2860
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Loss of Keap1 function activat ...... s for lung cancer cell growth.
@en
type
label
Loss of Keap1 function activat ...... s for lung cancer cell growth.
@en
prefLabel
Loss of Keap1 function activat ...... s for lung cancer cell growth.
@en
P2093
P1433
P1476
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
@en
P2093
Hiroshi Tanaka
Izumi Nakahara
Jun Yokota
Kumiko Iijima
Makiko Ohtsuji
Mamiko Miyamoto
Masayuki Yamamoto
Setsuo Hirohashi
Tatsuhiro Shibata
Tokuki Sakiyama
P304
P356
10.1158/0008-5472.CAN-07-5003
P407
P577
2008-03-01T00:00:00Z