Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth. - Wikidata - wikimedia - TriplyDB

Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.

Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.

http://www.wikidata.org/entity/Q40006300

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Update on the Kelch-like (KLHL) gene family Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2 NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activation Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy Mitochondria, cholesterol and cancer cell metabolism Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic Implications Squamous cell carcinomas of the lung and of the head and neck: new insights on molecular characterization Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance Redox Regulation in Cancer Stem Cells Roles nrf2 plays in myeloid cells and related disorders Structural Basis of Alternative DNA Recognition by Maf Transcription Factors Drugging the addict: non-oncogene addiction as a target for cancer therapy Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms Glycogen synthase kinase 3 regulates expression of nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) and inhibits pro-survival function of Nrf1 Nrf2 is a potential prognostic marker and promotes proliferation and invasion in human hepatocellular carcinoma Stress-activated cap'n'collar transcription factors in aging and human disease CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2 Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents Arsenic-mediated activation of the Nrf2-Keap1 antioxidant pathway Intronic DNA elements regulate Nrf2 chemical responsiveness of the human microsomal epoxide hydrolase gene (EPHX1) through a far upstream alternative promoter Progress and prospects of reactive oxygen species in metal carcinogenesis The complexity of the Nrf2 pathway: beyond the antioxidant response Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism p62 links autophagy and Nrf2 signaling Nrf2 signaling and cell survival Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer A new model for raf kinase inhibitory protein induced chemotherapeutic resistance Nrf2:INrf2 (Keap1) signaling in oxidative stress Genetic disruption of KEAP1/CUL3 E3 ubiquitin ligase complex components is a key mechanism of NF-kappaB pathway activation in lung cancer.Spotlite: web application and augmented algorithms for predicting co-complexed proteins from affinity purification--mass spectrometry data.Generation of a New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B1 Toxicity.NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation.The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel.WDR23 regulates NRF2 independently of KEAP1.Role of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2 Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene.Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains

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Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.

http://www.wikidata.org/entity/Q40006300

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年學術文章

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2008年學術文章

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2008年學術文章

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Loss of Keap1 function activat ...... s for lung cancer cell growth.

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type

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Loss of Keap1 function activat ...... s for lung cancer cell growth.

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Loss of Keap1 function activat ...... s for lung cancer cell growth.

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0008-5472.CAN-07-5003

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Cancer Research

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Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth

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Hiroshi Tanaka

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Izumi Nakahara

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Jun Yokota

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Kumiko Iijima

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Makiko Ohtsuji

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Mamiko Miyamoto

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Masayuki Yamamoto

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Setsuo Hirohashi

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Tatsuhiro Shibata

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Tokuki Sakiyama

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1303-1309

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scholarly article

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10.1158/0008-5472.CAN-07-5003

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5

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68

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Akira Kobayashi

Takafumi Suzuki

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2008-03-01T00:00:00Z

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5534847

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