Development of novobiocin analogues that manifest anti-proliferative activity against several cancer cell lines.
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The 'active life' of Hsp90 complexesElucidation of the Hsp90 C-terminal inhibitor binding siteDevelopment and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells.Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold.The synthesis and evaluation of flavone and isoflavone chimeras of novobiocin and derruboneHigh throughput discovery of heteroaromatic-modifying enzymes allows enhancement of novobiocin selectivity.Novobiocin analogues with second-generation noviose surrogates.Probing molecular mechanisms of the Hsp90 chaperone: biophysical modeling identifies key regulators of functional dynamics.3-Arylcoumarin derivatives manifest anti-proliferative activity through Hsp90 inhibition.3D-QSAR Assisted Design, Synthesis and Evaluation of Novobiocin Analogues.The impact of enzyme engineering upon natural product glycodiversificationDevelopment of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors.Engineering an antibiotic to fight cancer: optimization of the novobiocin scaffold to produce anti-proliferative agents.Novologues containing a benzamide side chain manifest anti-proliferative activity against two breast cancer cell lines.Design, synthesis, and biological evaluation of ring-constrained novobiocin analogues as hsp90 C-terminal inhibitorsKU675, a Concomitant Heat-Shock Protein Inhibitor of Hsp90 and Hsc70 that Manifests Isoform Selectivity for Hsp90α in Prostate Cancer CellsThe Chemical Biology of Molecular Chaperones--Implications for Modulation of ProteostasisSynthesis and evaluation of novologues as C-terminal Hsp90 inhibitors with cytoprotective activity against sensory neuron glucotoxicity.A systematic protocol for the characterization of Hsp90 modulators.Development of Noviomimetics as C-Terminal Hsp90 InhibitorsGedunin inactivates the co-chaperone p23 protein causing cancer cell death by apoptosis.Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix.Natural product inhibitors of Hsp90: potential leads for drug discoveryNovobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket.KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cellsAlternate strategies of Hsp90 modulation for the treatment of cancer and other diseases.Novel therapeutic strategies in multiple myeloma: role of the heat shock protein inhibitors.HSP90: chaperone-me-not.Synthesis and Evaluation of Noviose Replacements on Novobiocin that Manifest Anti-proliferative Activity.Synthesis and biological evaluation of coumarin replacements of novobiocin as Hsp90 inhibitors.Targeting the heat shock protein 90 dimer with dimeric inhibitors.Design, synthesis and biological evaluation of alkylamino biphenylamides as Hsp90 C-terminal inhibitors.Anticancer Inhibitors of Hsp90 Function: Beyond the Usual Suspects.Development of radamide analogs as Grp94 inhibitorsAlternative approaches to Hsp90 modulation for the treatment of cancer.A facile transformation of amino acids to functionalized coumarins.Click chemistry to probe Hsp90: Synthesis and evaluation of a series of triazole-containing novobiocin analogues.Identification of a new scaffold for hsp90 C-terminal inhibitionCharacterization of a novel novobiocin analogue as a putative C-terminal inhibitor of heat shock protein 90 in prostate cancer cells.Design, synthesis and biological evaluation of biphenylamide derivatives as Hsp90 C-terminal inhibitors
P2860
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P2860
Development of novobiocin analogues that manifest anti-proliferative activity against several cancer cell lines.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Development of novobiocin anal ...... nst several cancer cell lines.
@en
type
label
Development of novobiocin anal ...... nst several cancer cell lines.
@en
prefLabel
Development of novobiocin anal ...... nst several cancer cell lines.
@en
P2093
P356
P1476
Development of novobiocin anal ...... nst several cancer cell lines.
@en
P2093
Brian S J Blagg
Christopher Avila
Donna J Lubbers
George Vielhauer
Jeffrey Holzbeierlein
Joseph A Burlison
P304
P356
10.1021/JO702191A
P407
P577
2008-02-23T00:00:00Z