Clustered charged-to-alanine mutagenesis of poliovirus RNA-dependent RNA polymerase yields multiple temperature-sensitive mutants defective in RNA synthesis.
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mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A.Stimulation of poliovirus RNA synthesis and virus maturation in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDproFunctional and genetic analysis of coronavirus replicase-transcriptase proteinsThe predicted metal-binding region of the arterivirus helicase protein is involved in subgenomic mRNA synthesis, genome replication, and virion biogenesis.Mutagenesis of the Dengue virus type 2 NS3 protein within and outside helicase motifs: effects on enzyme activity and virus replication.Paired charge-to-alanine mutagenesis of dengue virus type 4 NS5 generates mutants with temperature-sensitive, host range, and mouse attenuation phenotypes.Crystal Structure of Poliovirus 3CD Protein: Virally Encoded Protease and Precursor to the RNA-Dependent RNA PolymeraseEffects of charged cluster mutations on the function of herpes simplex virus type 1 UL34 protein.Analysis of murine hepatitis virus strain A59 temperature-sensitive mutant TS-LA6 suggests that nsp10 plays a critical role in polyprotein processingLow Temperature Treatment Affects Concentration and Distribution of Chrysanthemum Stunt Viroid in Argyranthemum.Enzymatic and nonenzymatic functions of viral RNA-dependent RNA polymerases within oligomeric arrays.Stimulation of poliovirus synthesis in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDproConstruction and characterization of a temperature-sensitive human immunodeficiency virus type 1 reverse transcriptase mutantAnalysis of constructed E gene mutants of mouse hepatitis virus confirms a pivotal role for E protein in coronavirus assemblyClustered charge-to-alanine mutagenesis of the vaccinia virus H5 gene: isolation of a dominant, temperature-sensitive mutant with a profound defect in morphogenesisStralSV: assessment of sequence variability within similar 3D structures and application to polio RNA-dependent RNA polymeraseMolecular genetic analysis of U2AF59 in Schizosaccharomyces pombe: differential sensitivity of introns to mutational inactivation.Intramolecular and intermolecular uridylylation by poliovirus RNA-dependent RNA polymeraseMolecular dynamics simulations of viral RNA polymerases link conserved and correlated motions of functional elements to fidelityCharged residues in hepatitis C virus NS4B are critical for multiple NS4B functions in RNA replication.Targeted construction of temperature-sensitive mutations in vaccinia virus by replacing clustered charged residues with alanineMapping of mutations contributing to the temperature sensitivity of the Sabin 1 vaccine strain of poliovirusAn amino-terminal domain of the Sendai virus nucleocapsid protein is required for template function in viral RNA synthesis.Genetic dissection of interaction between poliovirus 3D polymerase and viral protein 3AB.Highly similar structural frames link the template tunnel and NTP entry tunnel to the exterior surface in RNA-dependent RNA polymerases.Structural features of a picornavirus polymerase involved in the polyadenylation of viral RNA.Mapping of the tacaribe arenavirus Z-protein binding sites on the L protein identified both amino acids within the putative polymerase domain and a region at the N terminus of L that are critically involved in binding.Expanding knowledge of P3 proteins in the poliovirus lifecycle.Picornavirus genome replication. Identification of the surface of the poliovirus (PV) 3C dimer that interacts with PV 3Dpol during VPg uridylylation and construction of a structural model for the PV 3C2-3Dpol complexSimilar interactions of the poliovirus and rhinovirus 3D polymerases with the 3' untranslated region of rhinovirus 14.Functional coupling between replication and packaging of poliovirus replicon RNACharge-to-alanine mutagenesis of the adeno-associated virus type 2 Rep78/68 proteins yields temperature-sensitive and magnesium-dependent variants.Oligomeric structures of poliovirus polymerase are important for function.Bypass suppression of small-plaque phenotypes by a mutation in poliovirus 2A that enhances apoptosis.Identification and characterization of a temperature-sensitive mutant of human immunodeficiency virus type 1 by alanine scanning mutagenesis of the integrase geneAn aspartic acid at amino acid 108 is required to rescue infectious virus after transfection of a poliovirus cDNA containing a CGDD but not SGDD amino acid motif in 3DpolMutation of lysine residues in the nucleotide binding segments of the poliovirus RNA-dependent RNA polymerase.Foot-and-mouth disease virus and poliovirus particles contain proteins of the replication complex.Molecular characterization of a novel cryptic virus infecting pigeonpea plants.Alanine scanning of poliovirus 2CATPase reveals new genetic evidence that capsid protein/2CATPase interactions are essential for morphogenesis.
P2860
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P2860
Clustered charged-to-alanine mutagenesis of poliovirus RNA-dependent RNA polymerase yields multiple temperature-sensitive mutants defective in RNA synthesis.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Clustered charged-to-alanine m ...... ts defective in RNA synthesis.
@en
type
label
Clustered charged-to-alanine m ...... ts defective in RNA synthesis.
@en
prefLabel
Clustered charged-to-alanine m ...... ts defective in RNA synthesis.
@en
P2860
P1433
P1476
Clustered charged-to-alanine m ...... ts defective in RNA synthesis.
@en
P2093
K Kirkegaard
S E Diamond
P2860
P304
P407
P577
1994-02-01T00:00:00Z