Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation.
about
HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiationE3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling.Ubiquitin ligases in oncogenic transformation and cancer therapy.Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis.Hepatic PPARα function is controlled by polyubiquitination and proteasome-mediated degradation via the coordinated actions of PAQR3 and HUWE1.Recent Advances in Intestinal Stem Cells.Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells.
P2860
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P2860
Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation.
description
2016 nî lūn-bûn
@nan
2016年の論文
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年学术文章
@zh-my
2016年学术文章
@zh-sg
2016年學術文章
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2016年學術文章
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2016年學術文章
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name
Mule Regulates the Intestinal ...... mal and Lysosomal Degradation.
@en
type
label
Mule Regulates the Intestinal ...... mal and Lysosomal Degradation.
@en
prefLabel
Mule Regulates the Intestinal ...... mal and Lysosomal Degradation.
@en
P2093
P2860
P50
P1433
P1476
Mule Regulates the Intestinal ...... mal and Lysosomal Degradation.
@en
P2093
Ana Marques
Andrew J Elia
Andrew Wakeham
Carmen Dominguez-Brauer
Colin Reardon
Hans Clevers
Iok In Christine Chio
Jennifer Silvester
Jillian Haight
Johan H van Es
P2860
P304
P356
10.1016/J.STEM.2016.04.002
P407
P577
2016-05-11T00:00:00Z