Effectiveness of PSD95 inhibitors in permanent and transient focal ischemia in the rat.
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Current understanding of TRPM7 pharmacology and drug development for strokeA high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damageTargeting protein-protein interactions with trimeric ligands: high affinity inhibitors of the MAGUK protein familyCell Permeable Peptides: A Promising Tool to Deliver Neuroprotective Agents in the Brain.Efficacy of the PSD95 inhibitor Tat-NR2B9c in mice requires dose translation between species.Neuroprotective effects of volume-regulated anion channel blocker DCPIB on neonatal hypoxic-ischemic injury.A novel approach to induction and rehabilitation of deficits in forelimb function in a rat model of ischemic stroke.Restoring neuroprotection through a new preclinical paradigm: translational success for NA-1 in stroke therapyEffective post-insult neuroprotection by a novel Ca(2+)/ calmodulin-dependent protein kinase II (CaMKII) inhibitor.Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing.Procaspase-9 induces its cleavage by transnitrosylating XIAP via the Thioredoxin system during cerebral ischemia-reperfusion in rats.Induction of ischemic stroke in awake freely moving mice reveals that isoflurane anesthesia can mask the benefits of a neuroprotection therapy.AMPA receptors as drug targets in neurological disease--advantages, caveats, and future outlook.Scaffolding proteins of the post-synaptic density contribute to synaptic plasticity by regulating receptor localization and distribution: relevance for neuropsychiatric diseases.Serotonin-glutamate and serotonin-dopamine reciprocal interactions as putative molecular targets for novel antipsychotic treatments: from receptor heterodimers to postsynaptic scaffolding and effector proteins.Ginsenoside Rd for acute ischemic stroke: translating from bench to bedside.Ligand-gated ion channel interacting proteins and their role in neuroprotection.Effect of sex and age interactions on functional outcome after stroke.Effects of Dimeric PSD-95 Inhibition on Excitotoxic Cell Death and Outcome After Controlled Cortical Impact in Rats.Disruption of the nuclear p53-GAPDH complex protects against ischemia-induced neuronal damage.Treating the Synapse in Major Psychiatric Disorders: The Role of Postsynaptic Density Network in Dopamine-Glutamate Interplay and Psychopharmacologic Drugs Molecular ActionsIn vitro and in vivo effects of a novel dimeric inhibitor of PSD-95 on excitotoxicity and functional recovery after experimental traumatic brain injury.Commemorating John F. MacDonald and the Art of Being a Mentor.Peptide Pharmacological Approaches to Treating Traumatic Brain Injury: a Case for Arginine-Rich Peptides.Calmodulin kinase IV-dependent CREB activation is required for neuroprotection via NMDA receptor-PSD95 disruption.Protein kinase A-phosphorylated KV1 channels in PSD95 signaling complex contribute to the resting membrane potential and diameter of cerebral arteriesIntegrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants.The R18 Polyarginine Peptide Is More Effective Than the TAT-NR2B9c (NA-1) Peptide When Administered 60 Minutes after Permanent Middle Cerebral Artery Occlusion in the Rat.Disruption of nNOS-PSD95 protein-protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents.Chimeric Peptide Tat-HA-NR2B9c Improves Regenerative Repair after Transient Global Ischemia.Uncoupling PSD-95 interactions leads to rapid recovery of cortical function after focal stroke.Sigma receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine modulates neuronal nitric oxide synthase/postsynaptic density-95 coupling mechanisms and protects against neonatal ischemic degeneration of striatal neurons.The truth in complexes: perspectives on ion channel signaling nexuses in the nervous system.Neuroprotective Effects of a PSD-95 Inhibitor in Neonatal Hypoxic-Ischemic Brain Injury.Are sigma receptor modulators a weapon against multiple sclerosis disease?Molecular determinants of beta-adrenergic signaling to voltage-gated K+ channels in the cerebral circulation.Peroxisome proliferator-activated receptor-γ (PPAR-γ) activation confers functional neuroprotection in global ischemia.Effects of α7 Nicotinic Receptor Activation on Cell Survival in Rat Organotypic Hippocampal Slice Cultures.Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain.TAT-PEP Enhanced Neurobehavioral Functional Recovery by Facilitating Axonal Regeneration and Corticospinal Tract Projection After Stroke.
P2860
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P2860
Effectiveness of PSD95 inhibitors in permanent and transient focal ischemia in the rat.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Effectiveness of PSD95 inhibitors in permanent and transient focal ischemia in the rat.
@en
type
label
Effectiveness of PSD95 inhibitors in permanent and transient focal ischemia in the rat.
@en
prefLabel
Effectiveness of PSD95 inhibitors in permanent and transient focal ischemia in the rat.
@en
P2093
P1433
P1476
Effectiveness of PSD95 inhibitors in permanent and transient focal ischemia in the rat
@en
P2093
Anthony Lau
Catherine L Ryan
Hong-Shuo Sun
Joan P Forder
Lucy Teves
Michael Tymianski
Michael W Salter
Paul B Bernard
R Andrew Tasker
Tracy A Doucette
P304
P356
10.1161/STROKEAHA.107.506048
P407
P577
2008-07-10T00:00:00Z