The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression.
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The Mucosal Immune System and Its Regulation by AutophagyIntersection of autophagy with pathways of antigen presentationAutophagy and the regulation of the immune responseStructure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes.A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagyImmunologic manifestations of autophagySignaling by the phosphoinositide 3-kinase family in immune cellsRegulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesisMiz1 is required to maintain autophagic flux.Histone deacetylase 3 is required for iNKT cell developmentCrosstalk between apoptosis and autophagy: molecular mechanisms and therapeutic strategies in cancer.Invariant NKT cells require autophagy to coordinate proliferation and survival signals during differentiation.Canonical autophagy dependent on the class III phosphoinositide-3 kinase Vps34 is required for naive T-cell homeostasis.Autophagy: an emerging immunological paradigm.The major isoforms of Bim contribute to distinct biological activities that govern the processes of autophagy and apoptosis in interleukin-7 dependent lymphocytes.Autophagy in immunity: implications in etiology of autoimmune/autoinflammatory diseasesThe role of lipids in the control of autophagyImpaired autophagy, defective T cell homeostasis, and a wasting syndrome in mice with a T cell-specific deletion of Vps34.The Nuclear Zinc Finger Protein Zfat Maintains FoxO1 Protein Levels in Peripheral T Cells by Regulating the Activities of Autophagy and the Akt Signaling Pathway.Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal diseaseKey roles of autophagy in regulating T-cell functionThe crosstalk between autophagy and apoptosis: where does this lead?IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasisMacroautophagy in T lymphocyte development and functionThe contribution of autophagy to lymphocyte survival and homeostasis.Self-eating and self-defense: autophagy controls innate immunity and adaptive immunity.Phosphoinositide 3-kinases as accelerators and brakes of autophagy.Autophagy inhibitors.IL-7 induces clathrin-mediated endocytosis of CD127 and subsequent degradation by the proteasome in primary human CD8 T cells.c-FLIP protects T lymphocytes from apoptosis in the intrinsic pathwayCharacteristics and requirements of basal autophagy in HEK 293 cells.Autophagy, a novel pathway to regulate calcium mobilization in T lymphocytes.A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytesVps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism.Life and Death of Activated T Cells: How Are They Different from Naïve T Cells?Cell-Intrinsic Roles for Autophagy in Modulating CD4 T Cell Functions.Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish.
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P2860
The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
The class III kinase Vps34 pro ...... ing IL-7Rα surface expression.
@en
type
label
The class III kinase Vps34 pro ...... ing IL-7Rα surface expression.
@en
prefLabel
The class III kinase Vps34 pro ...... ing IL-7Rα surface expression.
@en
P2093
P2860
P356
P1476
The class III kinase Vps34 pro ...... ing IL-7Rα surface expression.
@en
P2093
Ian X McLeod
Qi-Jing Li
Xiang Zhou
You-Wen He
P2860
P304
P356
10.4049/JIMMUNOL.1100710
P407
P577
2011-10-21T00:00:00Z