Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels.
about
The therapeutic profile of rolipram, PDE target and mechanism of action as a neuroprotectant following spinal cord injuryMechanisms for the modulation of dopamine d(1) receptor signaling in striatal neuronsMdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signalingNeuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapsesThe use of α-2A adrenergic agonists for the treatment of attention-deficit/hyperactivity disorderPhosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex.Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical ImplicationsPDE4 as a target for cognition enhancementThe role of ventral striatal cAMP signaling in stress-induced behaviors.The role of type 4 phosphodiesterases in generating microdomains of cAMP: large scale stochastic simulationsDISC1 at 10: connecting psychiatric genetics and neuroscienceThe DISC locus in psychiatric illnessDISC1-binding proteins in neural development, signalling and schizophreniaRACK1 and β-arrestin2 attenuate dimerization of PDE4 cAMP phosphodiesterase PDE4D5DISC1: Structure, Function, and Therapeutic Potential for Major Mental IllnessDisrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1Dixdc1 is a critical regulator of DISC1 and embryonic cortical developmentSpecific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory AcquisitionPrimary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases.Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3.Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models.Developmental etiology for neuroanatomical and cognitive deficits in mice overexpressing Galphas, a G-protein subunit genetically linked to schizophrenia.Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes.Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunction.708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits.Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascadeDISC1 and Huntington's disease--overlapping pathways of vulnerability to neurological disorder?Linking neurodevelopmental and synaptic theories of mental illness through DISC1Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia.EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function.Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domainsGuanfacine for the treatment of cognitive disorders: a century of discoveries at YaleAn odor-specific threshold deficit implicates abnormal cAMP signaling in youths at clinical risk for psychosis.A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins.Identification of a potent new chemotype for the selective inhibition of PDE4Disrupted-in-schizophrenia-1 Gln31Leu polymorphism results in social anhedonia associated with monoaminergic imbalance and reduction of CREB and β-arrestin-1,2 in the nucleus accumbens in a mouse model of depression.DISC1 genetics, biology and psychiatric illnessConstellation of HCN channels and cAMP regulating proteins in dendritic spines of the primate prefrontal cortex: potential substrate for working memory deficits in schizophrenia.
P2860
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P2860
Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Isoform-selective susceptibili ...... ted intracellular cAMP levels.
@en
type
label
Isoform-selective susceptibili ...... ted intracellular cAMP levels.
@en
prefLabel
Isoform-selective susceptibili ...... ted intracellular cAMP levels.
@en
P2093
P1476
Isoform-selective susceptibili ...... ated intracellular cAMP levels
@en
P2093
Daniel M Collins
Elaine V Hill
Enno Klussmann
Graeme B Bolger
Hannah Murdoch
J Kirsty Millar
Shaun Mackie
P304
P356
10.1523/JNEUROSCI.1493-07.2007
P407
P577
2007-08-01T00:00:00Z