Sensitivity of hepatitis C virus to cyclosporine A depends on nonstructural proteins NS5A and NS5B. - Wikidata - wikimedia - TriplyDB

Sensitivity of hepatitis C virus to cyclosporine A depends on nonstructural proteins NS5A and NS5B.

Sensitivity of hepatitis C virus to cyclosporine A depends on nonstructural proteins NS5A and NS5B.

http://www.wikidata.org/entity/Q40113778

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Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B Hepatitis C virus NS5B and host cyclophilin A share a common binding site on NS5A A single-amino-acid mutation in hepatitis C virus NS5A disrupting FKBP8 interaction impairs viral replication Chaperones in hepatitis C virus infection Cyclophilin A Is an Essential Cofactor for Hepatitis C Virus Infection and the Principal Mediator of Cyclosporine Resistance In Vitro Combinations of Cyclophilin Inhibitor NIM811 with Hepatitis C Virus NS3-4A Protease or NS5B Polymerase Inhibitors Enhance Antiviral Activity and Suppress the Emergence of Resistance Cyclophilin B stimulates RNA synthesis by the HCV RNA dependent RNA polymerase Hepatitis C Virus NS5A Protein Is a Substrate for the Peptidyl-prolyl cis/trans Isomerase Activity of Cyclophilins A and B Critical Role of Cyclophilin A and Its Prolyl-Peptidyl Isomerase Activity in the Structure and Function of the Hepatitis C Virus Replication Complex Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage Kinetics The Isomerase Active Site of Cyclophilin A Is Critical for Hepatitis C Virus Replication Mutations in the hepatitis C virus polymerase that increase RNA binding can confer resistance to cyclosporine A A Conserved Proline between Domains II and III of Hepatitis C Virus NS5A Influences both RNA Replication and Virus Assembly Cyclosporine Inhibits a Direct Interaction between Cyclophilins and Hepatitis C NS5A My Cousin, My Enemy: quasispecies suppression of drug resistance A cell-based assay for RNA synthesis by the HCV polymerase reveals new insights on mechanism of polymerase inhibitors and modulation by NS5A DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A A major determinant of cyclophilin dependence and cyclosporine susceptibility of hepatitis C virus identified by a genetic approach Increasing rate of cleavage at boundary between non-structural proteins 4B and 5A inhibits replication of hepatitis C virus.Ethanol and reactive species increase basal sequence heterogeneity of hepatitis C virus and produce variants with reduced susceptibility to antivirals.Evidence for separation of HCV subtype 1a into two distinct clades.Therapeutic implications of hepatitis C virus resistance to antiviral drugs.Targeting the non-structural proteins of hepatitis C virus: beyond hepatitis C virus protease and polymerase.Management of hepatitis C in patients with chronic kidney disease.Domain 3 of NS5A protein from the hepatitis C virus has intrinsic alpha-helical propensity and is a substrate of cyclophilin A.Choice of Biologic Therapy for Patients with Rheumatoid Arthritis: The Infection Perspective.Inhibitors of peptidyl proline isomerases as antivirals in hepatitis C and other viruses.Association of IL28B SNPs rs12979860 and rs8099917 on Hepatitis C Virus-RNA Status in Donors/Recipients of Living Donor Liver Transplantation.Expression of cyclophilin B is associated with malignant progression and regulation of genes implicated in the pathogenesis of breast cancer.Phenotypic analysis of NS5A variant from liver transplant patient with increased cyclosporine susceptibility Anti-HCV drugs in the pipeline.Cyclophilin A as a New Therapeutic Target for Hepatitis C Virus-induced Hepatocellular Carcinoma Cyclophilin inhibitors: a novel class of promising host-targeting anti-HCV agents.Cyclophilin inhibitors: an emerging class of therapeutics for the treatment of chronic hepatitis C infection Cyclophilins as modulators of viral replication.The role of immunophilins in viral infection.Suppression of viral RNA binding and the assembly of infectious hepatitis C virus particles in vitro by cyclophilin inhibitors.Cyclophilin inhibitors as a novel HCV therapy.Increased replicative fitness can lead to decreased drug sensitivity of hepatitis C virus.Subtype specific differences in NS5A domain II reveals involvement of proline at position 310 in cyclosporine susceptibility of hepatitis C virus

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P2860

Sensitivity of hepatitis C virus to cyclosporine A depends on nonstructural proteins NS5A and NS5B.

http://www.wikidata.org/entity/Q40113778

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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2007年學術文章

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Sensitivity of hepatitis C vir ...... ctural proteins NS5A and NS5B.

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Sensitivity of hepatitis C vir ...... ctural proteins NS5A and NS5B.

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Sensitivity of hepatitis C vir ...... ctural proteins NS5A and NS5B.

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Adin-Cristian Andrei

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Daniel S Poole

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Fiona Fernandes

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Justin Gerstner

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Rannveig Middleton

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Rob Striker

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1026-1033

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scholarly article

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10.1002/HEP.21809

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