Statin induced myotoxicity: the lactone forms are more potent than the acid forms in human skeletal muscle cells in vitro.
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Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs.Use of bedaquiline and delamanid in diabetes patients: clinical and pharmacological considerationsRNA-sequencing analysis of HepG2 cells treated with atorvastatinSimvastatin Sodium Salt and Fluvastatin Interact with Human Gap Junction Gamma-3 ProteinEffects of statins on skeletal muscle: a perspective for physical therapists.Simvastatin represses protein synthesis in the muscle-derived C₂C₁₂ cell line with a concomitant reduction in eukaryotic initiation factor 2B expressionParaoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone HydrolysisStatin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma.The SLCO1B1*5 genetic variant is associated with statin-induced side effects.Identification and Mechanistic Investigation of Drug-Drug Interactions Associated With Myopathy: A Translational Approach.Protection of rat skeletal muscle fibers by either L-carnitine or coenzyme Q10 against statins toxicity mediated by mitochondrial reactive oxygen generationEffect of cytochrome P450 3A5 genotype on atorvastatin pharmacokinetics and its interaction with clarithromycin.Charge effect of a liposomal delivery system encapsulating simvastatin to treat experimental ischemic stroke in ratsThe role of acid-base imbalance in statin-induced myotoxicityEffect of diabetes mellitus on pharmacokinetic and pharmacodynamic properties of drugs.Exploitation of pleiotropic actions of statins by using tumour-targeted delivery systems.Atorvastatin metabolite measurements as a diagnostic tool for statin-induced myopathy.Simvastatin inhibits glucose metabolism and legumain activity in human myotubes.Clinical and pharmacological hallmarks of rifapentine's use in diabetes patients with active and latent tuberculosis: do we know enough?UDP-glucuronosyltransferase (UGT) polymorphisms affect atorvastatin lactonization in vitro and in vivo.Impact of OATP1B1, MDR1, and CYP3A4 expression in liver and intestine on interpatient pharmacokinetic variability of atorvastatin in obese subjects.A simple assay for the simultaneous determination of rosuvastatin acid, rosuvastatin-5S-lactone, and N-desmethyl rosuvastatin in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS).Development and validation of a sensitive, simple, and rapid method for simultaneous quantitation of atorvastatin and its acid and lactone metabolites by liquid chromatography-tandem mass spectrometry (LC-MS/MS).Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform.The sensitivity of head and neck carcinoma cells to statins is related to the expression of their Ras expression status, and statin-induced apoptosis is mediated via suppression of the Ras/ERK and Ras/mTOR pathways.Discovery of new druggable sites in the anti-cholesterol target HMG-CoA reductase by computational alanine scanning mutagenesis.Development, validation and application of a novel HPLC-MS/MS method for the quantification of atorvastatin, bisoprolol and clopidogrel in a large cardiovascular patient cohort
P2860
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P2860
Statin induced myotoxicity: the lactone forms are more potent than the acid forms in human skeletal muscle cells in vitro.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Statin induced myotoxicity: th ...... keletal muscle cells in vitro.
@en
type
label
Statin induced myotoxicity: th ...... keletal muscle cells in vitro.
@en
prefLabel
Statin induced myotoxicity: th ...... keletal muscle cells in vitro.
@en
P2093
P1476
Statin induced myotoxicity: th ...... keletal muscle cells in vitro.
@en
P2093
Anders Asberg
Ane Gedde-Dahl
Ine Blankenberg Skottheim
Kjersti Hoel
Solmaz Hejazifar
P304
P356
10.1016/J.EJPS.2007.12.009
P407
P577
2008-01-18T00:00:00Z