Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR.
about
Phase II study of dose-adjusted EPOCH and rituximab in untreated diffuse large B-cell lymphoma with analysis of germinal center and post-germinal center biomarkersA lesson for cancer research: placental microarray gene analysis in preeclampsiaTreatment of diffuse large B cell lymphomaStructure of the wild-type human BCL6 POZ domainA Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In VivoThe role of aberrant proteolysis in lymphomagenesisDiversity and complexity in DNA recognition by transcription factorsZinc finger protein ZBTB20 expression is increased in hepatocellular carcinoma and associated with poor prognosis.A data integration framework for prediction of transcription factor targets.Functional interaction of HTLV-1 tax protein with the POZ domain of the transcriptional repressor BCL6.A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas.Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells.ATM is down-regulated by N-Myc-regulated microRNA-421.Selective induction of DNA repair pathways in human B cells activated by CD4+ T cellsBCL6 is critical for the development of a diverse primary B cell repertoire.The Spi1/PU.1 transcription factor accelerates replication fork progression by increasing PP1 phosphatase in leukemiaApurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells.LITAF, a BCL6 target gene, regulates autophagy in mature B-cell lymphomas.BCL6 promoter interacts with far upstream sequences with greatly enhanced activating histone modifications in germinal center B cellsIdentification and characterization of the two isoforms of the vertebrate H2A.Z histone variant.DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas.E2A-positive gastric MALT lymphoma has weaker plasmacytoid infiltrates and stronger expression of the memory B-cell-associated miR-223: possible correlation with stage and treatment response.Msh6 protects mature B cells from lymphoma by preserving genomic stability.Down-regulation of MiR-127 facilitates hepatocyte proliferation during rat liver regeneration.The pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated.An ATM/Chk2-mediated DNA damage-responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cellsBCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanismsMechanism and regulation of class switch recombinationRegulation of cell differentiation by the DNA damage response.Transcriptional and epigenetic networks of helper T and innate lymphoid cells.Suppression of human B cell activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin involves altered regulation of B cell lymphoma-6.MicroRNA 155 control of p53 activity is context dependent and mediated by Aicda and Socs1.The LRF transcription factor regulates mature B cell development and the germinal center response in miceLKB1 inhibition of NF-κB in B cells prevents T follicular helper cell differentiation and germinal center formation.Quantitative modeling of the terminal differentiation of B cells and mechanisms of lymphomagenesis.Disregulated expression of the transcription factor ThPOK during T-cell development leads to high incidence of T-cell lymphomas.MiRNA inhibition in tissue engineering and regenerative medicine.POK/ZBTB proteins: an emerging family of proteins that regulate lymphoid development and functionBcl6 Is Required for Somatic Hypermutation and Gene Conversion in Chicken DT40 Cells.A Cancer and Leukemia Group B multi-center study of DA-EPOCH-rituximab in untreated diffuse large B-cell lymphoma with analysis of outcome by molecular subtype.
P2860
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P2860
Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Bcl-6 mediates the germinal ce ...... of the DNA-damage sensor ATR.
@en
type
label
Bcl-6 mediates the germinal ce ...... of the DNA-damage sensor ATR.
@en
prefLabel
Bcl-6 mediates the germinal ce ...... of the DNA-damage sensor ATR.
@en
P2093
P356
P1433
P1476
Bcl-6 mediates the germinal ce ...... of the DNA-damage sensor ATR.
@en
P2093
Ari Melnick
Jamil Dierov
John Greally
Jose M Polo
Martin Carroll
Michael Singer
Roland Green
Stella Maris Ranuncolo
P304
P356
10.1038/NI1478
P407
P577
2007-06-10T00:00:00Z