Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells.
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Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein responseBlockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myelomaIdentification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myelomaClinical use and applications of histone deacetylase inhibitors in multiple myelomaDangER: protein ovERload. Targeting protein degradation to treat myelomaNovel therapeutic strategies for multiple myelomaInduction of premature senescence by hsp90 inhibition in small cell lung cancerSynergistic apoptosis induction in leukemic cells by the phosphatase inhibitor salubrinal and proteasome inhibitorsDynamic impacts of the inhibition of the molecular chaperone Hsp90 on the T-cell proteome have implications for anti-cancer therapyConnecting gene expression data from connectivity map and in silico target predictions for small molecule mechanism-of-action analysis.Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways.A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complexSuppression of heat shock protein 27 using OGX-427 induces endoplasmic reticulum stress and potentiates heat shock protein 90 inhibitors to delay castrate-resistant prostate cancer.Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications.Role of CAAT/enhancer binding protein homologous protein in panobinostat-mediated potentiation of bortezomib-induced lethal endoplasmic reticulum stress in mantle cell lymphoma cells.The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1.Utilization of the cellular stress response to sensitize cancer cells to TRAIL-mediated apoptosis.Proteasome inhibition and its therapeutic potential in multiple myelomaTranscription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein responseEndoplasmic reticulum stress and cancer.Dinaciclib (SCH727965) inhibits the unfolded protein response through a CDK1- and 5-dependent mechanismIdentification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer.The DAC system and associations with multiple myeloma.Ubiquitination of inositol-requiring enzyme 1 (IRE1) by the E3 ligase CHIP mediates the IRE1/TRAF2/JNK pathway.Identification of autophosphorylation inhibitors of the inositol-requiring enzyme 1 alpha (IRE1α) by high-throughput screening using a DELFIA assay.Induction of tumor cell apoptosis by a proteasome deubiquitinase inhibitor is associated with oxidative stressThe natural human IgM antibody PAT-SM6 induces apoptosis in primary human multiple myeloma cells by targeting heat shock protein GRP78.The use of novel agents in the treatment of relapsed and refractory multiple myelomaAntimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101Cyclin D1 sensitizes myeloma cells to endoplasmic reticulum stress-mediated apoptosis by activating the unfolded protein response pathwayIdentification of known drugs targeting the endoplasmic reticulum stress response.Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses pro-survival XBP1 signaling in human multiple myeloma cells.A new strategy to ERADicate HER2-positive breast tumors?Cdc37/Hsp90 protein-mediated regulation of IRE1α protein activity in endoplasmic reticulum stress response and insulin synthesis in INS-1 cells.Hsp90 and hepatobiliary transformation during sea lamprey metamorphosis.Synergistic promotion of breast cancer cells death by targeting molecular chaperone GRP78 and heat shock protein 70.Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myelomaDifferential targeting of androgen and glucocorticoid receptors induces ER stress and apoptosis in prostate cancer cells: a novel therapeutic modality.Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma.Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress.
P2860
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P2860
Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Heat shock protein inhibition ...... thway in myeloma plasma cells.
@en
type
label
Heat shock protein inhibition ...... thway in myeloma plasma cells.
@en
prefLabel
Heat shock protein inhibition ...... thway in myeloma plasma cells.
@en
P2093
P1433
P1476
Heat shock protein inhibition ...... thway in myeloma plasma cells.
@en
P2093
Alan S Dunlop
Emma L Davenport
Faith E Davies
Gareth J Morgan
Hannah E Moore
Swee Y Sharp
P304
P356
10.1182/BLOOD-2006-11-053728
P407
P50
P577
2007-05-24T00:00:00Z