Expression and biochemical characterization of nsP2 cysteine protease of Chikungunya virus.
about
Mutations conferring a noncytotoxic phenotype on chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2Functional cross-talk between distant domains of chikungunya virus non-structural protein 2 is decisive for its RNA-modulating activityMolecular cloning, overproduction, purification and biochemical characterization of the p39 nsp2 protease domains encoded by three alphavirusesNTPase and 5'-RNA triphosphatase activities of Chikungunya virus nsP2 proteinHeat shock protein 90 positively regulates Chikungunya virus replication by stabilizing viral non-structural protein nsP2 during infectionPotential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses.A combination of doxycycline and ribavirin alleviated chikungunya infection.Full length and protease domain activity of chikungunya virus nsP2 differ from other alphavirus nsP2 proteases in recognition of small peptide substrates.Chikungunya nsP2 protease is not a papain-like cysteine protease and the catalytic dyad cysteine is interchangeable with a proximal serine.Design and Validation of Novel Chikungunya Virus Protease Inhibitors.Structure-function relationship of Chikungunya nsP2 protease: A comparative study with papain.Development of novel antibodies against non-structural proteins nsP1, nsP3 and nsP4 of chikungunya virus: potential use in basic research.Discovery of Novel Peptidomimetics as Irreversible CHIKV NsP2 Protease Inhibitors Using Quantum Mechanical-Based Ligand Descriptors.Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease's active site cysteine residue.Conformer and pharmacophore based identification of peptidomimetic inhibitors of chikungunya virus nsP2 protease.Structural basis for complementary and alternative medicine: Phytochemical interaction with non-structural protein 2 protease-a reverse engineering strategy.A compendium of small molecule direct-acting and host-targeting inhibitors as therapies against alphaviruses.Ubiquitin-Conjugating Enzyme E2 L3 is Downregulated by the Chikungunya Virus nsP2 Protease.Chikungunya virus nsP1 interacts directly with nsP2 and modulates its ATPase activity.Development of nsP2 protease based cell free high throughput screening assay for evaluation of inhibitors against emerging Chikungunya virusAedes aegypti mosquitoes from Guadeloupe (French West Indies) are able to transmit yellow fever virus
P2860
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P2860
Expression and biochemical characterization of nsP2 cysteine protease of Chikungunya virus.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Expression and biochemical cha ...... protease of Chikungunya virus.
@en
type
label
Expression and biochemical cha ...... protease of Chikungunya virus.
@en
prefLabel
Expression and biochemical cha ...... protease of Chikungunya virus.
@en
P2093
P50
P1433
P1476
Expression and biochemical cha ...... protease of Chikungunya virus.
@en
P2093
Boris A M Pastorino
Christophe N Peyrefitte
Dominique Rolland
Hugues J Tolou
P304
P356
10.1016/J.VIRUSRES.2007.09.009
P577
2007-10-24T00:00:00Z