Microwave-assisted synthesis of N-pyrazole ureas and the p38alpha inhibitor BIRB 796 for study into accelerated cell ageing.
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Research spotlight: Microwave chemistry enabling the synthesis of biologically relevant amines.Microwave-assisted synthesis of a pyrazolyl ketone library for evaluation as p38 MAPK inhibitors in Werner syndrome cells.Nijmegen breakage syndrome fibroblasts expressing the C-terminal truncated NBN(p70) protein undergo p38/MK2-dependent premature senescence.The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells.Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2.Can we intervene in human ageing?Approaches towards the synthesis of 5-aminopyrazoles.Synthesis and p38 Inhibitory Activity of Some Novel Substituted N,N'-Diarylurea Derivatives.Design, Synthesis and Biological Evaluation of Novel Substituted N,N'-Diaryl ureas as Potent p38 Inhibitors.Use of p38 MAPK Inhibitors for the Treatment of Werner Syndrome.Synthesis of the highly selective p38 MAPK inhibitor UR-13756 for possible therapeutic use in Werner syndrome.Gram-scale synthesis of the p38α MAPK-inhibitor VX-745 for preclinical studies into Werner syndrome.Microwave-Assisted Synthesis of a MK2 Inhibitor by Suzuki-Miyaura Coupling for Study in Werner Syndrome Cells.Evaluating the Role of p38 MAPK in the Accelerated Cell Senescence of Werner Syndrome Fibroblasts.IFN-α inhibits telomerase in human CD8⁺ T cells by both hTERT downregulation and induction of p38 MAPK signaling.Small molecule inhibition of p38 MAP kinase extends the replicative life span of human ATR-Seckel syndrome fibroblasts.Copper-catalysed oxidative C-H/N-H cross-coupling between formamides and amides through chelation-assisted N-H activation.Studies with beta-oxoalkanonitriles: simple novel synthesis of 3-[2,6-diaryl-4- pyridyl]-3-oxopropanenitriles.Microwave-assisted synthesis of 3-aminobenzo[b]thiophene scaffolds for the preparation of kinase inhibitors.Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation.
P2860
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P2860
Microwave-assisted synthesis of N-pyrazole ureas and the p38alpha inhibitor BIRB 796 for study into accelerated cell ageing.
description
2006 nî lūn-bûn
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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name
Microwave-assisted synthesis o ...... into accelerated cell ageing.
@en
type
label
Microwave-assisted synthesis o ...... into accelerated cell ageing.
@en
prefLabel
Microwave-assisted synthesis o ...... into accelerated cell ageing.
@en
P2093
P356
P1476
Microwave-assisted synthesis o ...... into accelerated cell ageing.
@en
P2093
Caroline S Widdowson
David Kipling
Mark C Bagley
Matthew C Dix
Terence Davis
P2860
P304
P356
10.1039/B611493H
P577
2006-11-01T00:00:00Z