Targeting CAL as a negative regulator of DeltaF508-CFTR cell-surface expression: an RNA interference and structure-based mutagenetic approach.
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Computational design of a PDZ domain peptide inhibitor that rescues CFTR activityThe deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cellsPDZ domains and their binding partners: structure, specificity, and modificationStereochemical Preferences Modulate Affinity and Selectivity among Five PDZ Domains that Bind CFTR: Comparative Structural and Sequence AnalysesMechanistic Approaches to Improve Correction of the Most Common Disease-Causing Mutation in Cystic FibrosisDifferential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice.Serum- and glucocorticoid-induced protein kinase 1 (SGK1) increases the cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells by phosphorylating Shank2E protein.Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator.Targeting the regulation of CFTR channels.Chemically modified peptide scaffolds target the CFTR-associated ligand PDZ domainTargets for cystic fibrosis therapy: proteomic analysis and correction of mutant cystic fibrosis transmembrane conductance regulatorCFTR chloride channel in the apical compartments: spatiotemporal coupling to its interacting partners.Ubiquitination and degradation of CFTR by the E3 ubiquitin ligase MARCH2 through its association with adaptor proteins CAL and STX6Crystallization and preliminary diffraction analysis of the CAL PDZ domain in complex with a selective peptide inhibitorIntracellular Delivery of Peptidyl Ligands by Reversible Cyclization: Discovery of a PDZ Domain Inhibitor that Rescues CFTR Activity.Arsenic promotes ubiquitinylation and lysosomal degradation of cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels in human airway epithelial cellsTissue-specific control of CFTR endocytosis by Dab2: Cargo recruitment as a therapeutic target.Reduced PDZ interactions of rescued ΔF508CFTR increases its cell surface mobility.c-Cbl reduces stability of rescued ∆F508-CFTR in human airway epithelial cells: Implications for cystic fibrosis treatment.MAST205 competes with cystic fibrosis transmembrane conductance regulator (CFTR)-associated ligand for binding to CFTR to regulate CFTR-mediated fluid transportRepairing the basic defect in cystic fibrosis - one approach is not enough.Effects of Pseudomonas aeruginosa on CFTR chloride secretion and the host immune response.Beta-oestradiol rescues DeltaF508CFTR functional expression in human cystic fibrosis airway CFBE41o- cells through the up-regulation of NHERF1.CFTR-NHERF2-LPA₂ Complex in the Airway and Gut Epithelia.The relative binding affinities of PDZ partners for CFTR: a biochemical basis for efficient endocytic recycling.A stabilizing influence: CAL PDZ inhibition extends the half-life of ΔF508-CFTR.The CFTR-Associated Ligand Arrests the Trafficking of the Mutant ΔF508 CFTR Channel in the ER Contributing to Cystic Fibrosis.The CFTR trafficking mutation F508del inhibits the constitutive activity of SLC26A9.Role of the SLC26A9 Chloride Channel as Disease Modifier and Potential Therapeutic Target in Cystic FibrosisPeripheral Protein Quality Control as a Novel Drug Target for CFTR Stabilizer
P2860
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P2860
Targeting CAL as a negative regulator of DeltaF508-CFTR cell-surface expression: an RNA interference and structure-based mutagenetic approach.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Targeting CAL as a negative re ...... re-based mutagenetic approach.
@en
type
label
Targeting CAL as a negative re ...... re-based mutagenetic approach.
@en
prefLabel
Targeting CAL as a negative re ...... re-based mutagenetic approach.
@en
P2093
P2860
P356
P1476
Targeting CAL as a negative re ...... re-based mutagenetic approach.
@en
P2093
Abigail Fellows
Aleksandr Kivenson
Andrea Piserchio
Bonita Coutermarsh
Bruce A Stanton
Dale F Mierke
Dean R Madden
Katherine Karlson
Laleh Talebian
P2860
P304
P356
10.1074/JBC.M611049200
P407
P577
2006-12-11T00:00:00Z