Amelioration of diabetes by imatinib mesylate (Gleevec): role of beta-cell NF-kappaB activation and anti-apoptotic preconditioning.
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Effects of Imatinib Mesylate (Gleevec) on human islet NF-kappaB activation and chemokine production in vitroThe tyrphostin agent AG490 prevents and reverses type 1 diabetes in NOD miceEndocrine side effects of broad-acting kinase inhibitors.Inhibition of nuclear factor-κB activation in pancreatic β-cells has a protective effect on allogeneic pancreatic islet graft survivalSmall-molecule inhibition of inflammatory β-cell death.The endoplasmic reticulum stress response and diabetic kidney disease.S phase entry causes homocysteine-induced death while ataxia telangiectasia and Rad3 related protein functions anti-apoptotically to protect neurons.Islet transplantation and encapsulation: an update on recent developmentsC-Abl inhibitor imatinib enhances insulin production by β cells: c-Abl negatively regulates insulin production via interfering with the expression of NKx2.2 and GLUT-2.Polyphenols isolated from Broussonetia kazinoki prevent cytokine-induced β-cell damage and the development of type 1 diabetesInfluence of Tyrphostin AG490 on the expression of diabetes-associated markers in human adipocytes.Selective targeting of c-Abl via a cryptic mitochondrial targeting signal activated by cellular redox status in leukemic and breast cancer cells.Oxidative Stress Type Influences the Properties of Antioxidants Containing Polyphenols in RINm5F Beta Cells.Targeting Abl kinases to regulate vascular leak during sepsis and acute respiratory distress syndrome.Imatinib attenuates inflammation and vascular leak in a clinically relevant two-hit model of acute lung injuryBlood glucose levels in patients with metastatic renal cell carcinoma treated with sunitinib.Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice.AMP-dependent kinase inhibits oxidative stress-induced caveolin-1 phosphorylation and endocytosis by suppressing the dissociation between c-Abl and Prdx1 proteins in endothelial cellsInhibition of VEGFR-2 reverses type 1 diabetes in NOD mice by abrogating insulitis and restoring islet functionTransformation of nonfunctioning pancreatic neuroendocrine carcinoma cells into insulin producing cells after treatment with sunitinibInhibition of c-Kit is not required for reversal of hyperglycemia by imatinib in NOD mice.Potential utility of small tyrosine kinase inhibitors in the treatment of diabetes.PPARγ Antagonist Gleevec Improves Insulin Sensitivity and Promotes the Browning of White Adipose Tissue.The safety profile of imatinib in CML and GIST: long-term considerations.Does the small tyrosine kinase inhibitor Imatinib mesylate counteract diabetes by affecting pancreatic islet amyloidosis and fibrosis?Tyrosine kinase inhibitors as novel drugs for the treatment of diabetes.Impact of comorbidities on the treatment of chronic myeloid leukemia with tyrosine-kinase inhibitors.Combination Immunotherapy for Type 1 Diabetes.Tyrosine kinase inhibitors under investigation for the treatment of type II diabetes.Recognizing Endocrinopathies Associated With Tyrosine Kinase Inhibitor Therapy in Children With Chronic Myelogenous Leukemia.Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes.Novel members of quinoline compound family enhance insulin secretion in RIN-5AH beta cells and in rat pancreatic islet microtissue.Imatinib mesylate reduces endoplasmic reticulum stress and induces remission of diabetes in db/db mice.Uncoupling protein-2 increases nitric oxide production and TNFAIP3 pathway activation in pancreatic islets.Effect of imatinib on the biochemical parameters of the reproductive function in male Swiss albino miceImatinib prevents beta cell death in vitro but does not improve islet transplantation outcome.Imatinib mesylate stimulates low-density lipoprotein receptor-related protein 1-mediated ERK phosphorylation in insulin-producing cells.mRNA of the pro-apoptotic gene BBC3 serves as a molecular marker for TNF-α-induced islet damage in humans.Overexpression of the nuclear factor-κB subunit c-Rel protects against human islet cell death in vitro.Sunitinib-induced severe hypoglycemia in a diabetic patient.
P2860
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P2860
Amelioration of diabetes by imatinib mesylate (Gleevec): role of beta-cell NF-kappaB activation and anti-apoptotic preconditioning.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Amelioration of diabetes by im ...... nti-apoptotic preconditioning.
@en
type
label
Amelioration of diabetes by im ...... nti-apoptotic preconditioning.
@en
prefLabel
Amelioration of diabetes by im ...... nti-apoptotic preconditioning.
@en
P2093
P356
P1433
P1476
Amelioration of diabetes by im ...... nti-apoptotic preconditioning.
@en
P2093
Dariush Mokhtari
Nils Welsh
Robert Hägerkvist
P304
P356
10.1096/FJ.06-6910COM
P407
P577
2006-11-29T00:00:00Z