about
In vivo imaging reveals sigmoidal growth kinetic of β-amyloid plaques.Development and implementation of a high-throughput compound screening assay for targeting disrupted ER calcium homeostasis in Alzheimer's diseaseA disintegrin and metalloproteinase 17 (ADAM17) mediates inflammation-induced shedding of syndecan-1 and -4 by lung epithelial cellsSynthesis and biological evaluation of glycogen synthase kinase 3 (GSK-3) inhibitors: an fast and atom efficient access to 1-aryl-3-benzylureas.Biodistribution and Efficacy Studies of the Proteasome Inhibitor BSc2118 in a Mouse Melanoma ModelLong-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice.Immunotherapy alleviates amyloid-associated synaptic pathology in an Alzheimer's disease mouse model.Membrane anchoring γ-secretase modulators with terpene-derived moieties.Development of tau aggregation inhibitors for Alzheimer's disease.Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites.Computer-guided design, synthesis, and biological evaluation of quinoxalinebisarylureas as FLT3 inhibitors.Small molecule kinase inhibitors for LRRK2 and their application to Parkinson's disease models.Soluble CD23 controls IgE synthesis and homeostasis in human B cells.Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease ModelsDrug development and PET-diagnostics for Alzheimer's disease.Modulators and inhibitors of gamma- and beta-secretases.Curcumin derivatives inhibit or modulate beta-amyloid precursor protein metabolism.Substrate-targeting gamma-secretase modulatorsCurcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanismsFluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer's disease brains.Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3α.NSAID-derived γ-secretase modulation requires an acidic moiety on the carbazole scaffold.Improved synthesis of ADAM10 inhibitor GI254023X.Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells.Combined effect of proteasome and calpain inhibition on cisplatin-resistant human melanoma cells.Regulation of peroxisome proliferator-activated receptor gamma activity by losartan metabolites.Inhibition of gamma-secretase by the CK1 inhibitor IC261 does not depend on CK1delta.NSAID-derived gamma-secretase modulators. Part III: Membrane anchoring.Angiotensin II receptor-independent antiinflammatory and antiaggregatory properties of losartan: role of the active metabolite EXP3179.Design, synthesis and biological evaluation of trimethine cyanine dyes as fluorescent probes for the detection of tau fibrils in Alzheimer's disease brain and olfactory epithelium.3-[2,6-Bis(diethylcarbamoyl)pyridin-4-yl]-N-(tert-butoxycarbonyl)alanine methyl ester: a chiral tridentate ligand that causes a diastereomeric excess of its lanthanide complexes in solution.Copper dipicolinates as peptidomimetic ligands for the Src SH2 domain.Determinants of steady-state torasemide pharmacokinetics: impact of pharmacogenetic factors, gender and angiotensin II receptor blockers.Curcumin-derived pyrazoles and isoxazoles: Swiss army knives or blunt tools for Alzheimer's disease?An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin.Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases.Dysfunction of Somatostatin-Positive Interneurons Associated with Memory Deficits in an Alzheimer's Disease Model.Ensemble-docking approach on BACE-1: pharmacophore perception and guidelines for drug design.2-Styrylindolium based fluorescent probes visualize neurofibrillary tangles in Alzheimer's disease.Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils and β-amyloid plaques in Alzheimer's disease models.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Boris Schmidt
@ast
Boris Schmidt
@en
Boris Schmidt
@es
Boris Schmidt
@sl
type
label
Boris Schmidt
@ast
Boris Schmidt
@en
Boris Schmidt
@es
Boris Schmidt
@sl
prefLabel
Boris Schmidt
@ast
Boris Schmidt
@en
Boris Schmidt
@es
Boris Schmidt
@sl
P1053
D-3293-2009
P106
P1153
7402828225
P21
P31
P3829
P496
0000-0003-1662-2392