Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine.
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Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977A discriminative analytical method for detection of CES1A1 and CES1A2/CES1A3 genetic variantsPrediction of hepatic clearance in human from in vitro data for successful drug development.Structure-Activity Relationships of Pentacyclic Triterpenoids as Potent and Selective Inhibitors against Human Carboxylesterase 1Design of enzymatically cleavable prodrugs of a potent platinum-containing anticancer agent.Computer-aided retrometabolic drug design: soft drugs.Development of organophosphate hydrolase activity in a bacterial homolog of human cholinesterasePROTEOMIC ANALYSIS OF UBIQUITINATED PROTEINS FROM DELTAMETHRIN-RESISTANT AND SUSCEPTIBLE STRAINS OF THE DIAMONDBACK MOTH, Plutella Xylostella L.Effects of alcohol on human carboxylesterase drug metabolism.Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and cThe role of human carboxylesterases in drug metabolism: have we overlooked their importance?Conventional liquid chromatography/triple quadrupole mass spectrometry based metabolite identification and semi-quantitative estimation approach in the investigation of in vitro dabigatran etexilate metabolism.Interspecies Differences in the Metabolism of a Multiester Prodrug by CarboxylesterasesStructure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs.Hydrolysis of pyrethroids by human and rat tissues: examination of intestinal, liver and serum carboxylesterases.Identification of carboxylesterase-dependent dabigatran etexilate hydrolysis.Cardiac drug-drug interaction between HCV-NS5B pronucleotide inhibitors and amiodarone is determined by their specific diastereochemistry.Association between copy number variation losses and alcohol dependence across African American and European American ethnic groups.Methylparaben and butylparaben alter multipotent mesenchymal stem cell fates towards adipocyte lineage.Arylacetamide Deacetylase is Responsible for Activation of Prasugrel in Human and Dog.CES1 genetic variation affects the activation of angiotensin-converting enzyme inhibitors.Metabolism and pharmacokinetics of the anti-hepatitis C virus nucleotide prodrug GS-6620.Contributions of intestine and plasma to the presystemic bioconversion of vicagrel, an acetate of clopidogrel.Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender.Carboxylesterases in lipid metabolism: from mouse to human.Association of Oseltamivir Activation with Gender and Carboxylesterase 1 Genetic Polymorphisms.Linker design for the modular assembly of multifunctional and targeted platinum(ii)-containing anticancer agents.Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities.Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR.Development of a Novel Formulation That Improves Preclinical Bioavailability of Tenofovir Disoproxil Fumarate.Involvement of Carboxylesterase in Hydrolysis of Propranolol Prodrug during Permeation across Rat Skin.The effect of carboxylesterase 1 (CES1) polymorphisms on the pharmacokinetics of oseltamivir in humans.Comparative study of the hydrolytic metabolism of methyl-, ethyl-, propyl-, butyl-, heptyl- and dodecylparaben by microsomes of various rat and human tissues.In vitro metabolism of pyripyropene A and ACAT inhibitory activity of its metabolites.Development of amide-based fluorescent probes for selective measurement of carboxylesterase 1 activity in tissue extracts.Cellular Pharmacokinetic Model-Based Analysis of Genistein, Glyceollin, and MK-571 Effects on 5 (and 6)-Carboxy-2',7'-Dichloroflourescein Disposition in Caco-2 Cells.Reappraisal of the genetic diversity and pharmacogenetic assessment of CES1.Differential effects on adiposity and serum marker of bone formation by post-weaning exposure to methylparaben and butylparaben.Novel Genetic Variants in Carboxylesterase 1 Predict Severe Early-Onset Capecitabine-Related Toxicity.Scaffold Optimisation of Tetravalent Antagonists of the Mannose Binding Lectin.
P2860
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P2860
Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Substrate specificity of carbo ...... man liver and small intestine.
@en
type
label
Substrate specificity of carbo ...... man liver and small intestine.
@en
prefLabel
Substrate specificity of carbo ...... man liver and small intestine.
@en
P2093
P356
P1476
Substrate specificity of carbo ...... man liver and small intestine.
@en
P2093
Masakiyo Hosokawa
Mayumi Shii
Megumi Taketani
Teruko Imai
P304
P356
10.1124/DMD.106.009381
P577
2006-07-12T00:00:00Z