Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia.
about
Deletion of vanilloid receptor 1-expressing primary afferent neurons for pain controlTRPV1: a target for next generation analgesicsSubstance P-driven feed-forward inhibitory activity in the mammalian spinal cordCapsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical UsesEmerging Role of Spinal Cord TRPV1 in Pain ExacerbationUse of Capsaicin to Treat Pain: Mechanistic and Therapeutic ConsiderationsLigand-induced dynamic membrane changes and cell deletion conferred by vanilloid receptor 1Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation.Ablation of rat TRPV1-expressing Adelta/C-fibers with resiniferatoxin: analysis of withdrawal behaviors, recovery of function and molecular correlates.Selective targeting of TRPV1 expressing sensory nerve terminals in the spinal cord for long lasting analgesiaPain--mechanics and managementPain behavior in the formalin test persists after ablation of the great majority of C-fiber nociceptorsThe vanilloid agonist resiniferatoxin for interventional-based pain controlDistinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli.Persistent Nociception Triggered by Nerve Growth Factor (NGF) Is Mediated by TRPV1 and Oxidative Mechanisms.Regulation of pain sensitivity in the central nervous system.Differential effects of peripheral versus central coadministration of QX-314 and capsaicin on neuropathic pain in ratsSubstance P-mediated slow excitatory postsynaptic potential elicited in dorsal horn neurons in vivo by noxious stimulation.Transient receptor potential channels in pain and inflammation: therapeutic opportunities.Capsicum--production, technology, chemistry, and quality. Part V. Impact on physiology, pharmacology, nutrition, and metabolism; structure, pungency, pain, and desensitization sequences.Capsaicin for neuropathic pain: linking traditional medicine and molecular biology.Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites.Current and Future Issues in the Development of Spinal Agents for the Management of Pain.Effects of High-Dose Capsaicin on TMD Subjects: A Randomized Clinical Study.Mediation of Movement-Induced Breakthrough Cancer Pain by IB4-Binding Nociceptors in Rats.Selective antagonism of capsaicin by capsazepine: evidence for a spinal receptor site in capsaicin-induced antinociceptionIntrathecal Resiniferatoxin Modulates TRPV1 in DRG Neurons and Reduces TNF-Induced Pain-Related Behavior.Hyperalgesia produced by intrathecal substance P and related peptides: desensitization and cross desensitization.Depression of presynaptic excitation by the activation of vanilloid receptor 1 in the rat spinal dorsal horn revealed by optical imaging.Inhibition of substance P release is the key to successful management of oral pain.The permanent anatomical effects of neonatal capsaicin on somatosensory nerves.Plasticity of TRPV1-Expressing Sensory Neurons Mediating Autonomic Dysreflexia Following Spinal Cord Injury.The role of substance P in simultaneously mediating oral pain and inflammationEarly postnatal administration of 5,7-dihydroxytryptamine: effects on substance P and thyrotropin-releasing hormone neurons and terminals in rat brain.Effect of delayed intrathecal administration of capsaicin on neuropathic pain induced by chronic constriction injury of the sciatic nerve in rats.Importance of endogenous nitric oxide synthase in the rat hypothalamus and amygdala in mediating the response to capsaicin.An automated flinch detecting system for use in the formalin nociceptive bioassay.Developmental shift of vanilloid receptor 1 (VR1) terminals into deeper regions of the superficial dorsal horn: correlation with a shift from TrkA to Ret expression by dorsal root ganglion neurons.Use of a fluorescent imaging plate reader--based calcium assay to assess pharmacological differences between the human and rat vanilloid receptor.Pain control through selective chemo-axotomy of centrally projecting TRPV1+ sensory neurons.
P2860
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P2860
Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia.
description
1979 nî lūn-bûn
@nan
1979年の論文
@ja
1979年論文
@yue
1979年論文
@zh-hant
1979年論文
@zh-hk
1979年論文
@zh-mo
1979年論文
@zh-tw
1979年论文
@wuu
1979年论文
@zh
1979年论文
@zh-cn
name
Intrathecal capsaicin depletes ...... s prolonged thermal analgesia.
@en
type
label
Intrathecal capsaicin depletes ...... s prolonged thermal analgesia.
@en
prefLabel
Intrathecal capsaicin depletes ...... s prolonged thermal analgesia.
@en
P2093
P356
P1433
P1476
Intrathecal capsaicin depletes ...... s prolonged thermal analgesia.
@en
P2093
P304
P356
10.1126/SCIENCE.228392
P407
P577
1979-10-01T00:00:00Z