Process parameter shifting: Part I. Effect of DOT, pH, and temperature on the performance of Epo-Fc expressing CHO cells cultivated in controlled batch bioreactors.
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Advances in recombinant antibody manufacturingCombining mechanistic and data-driven approaches to gain process knowledge on the control of the metabolic shift to lactate uptake in a fed-batch CHO process.CellFrame: a data structure for abstraction of cell biology experiments and construction of perturbation networks.Low-Dose Paclitaxel Inhibits Tumor Cell Growth by Regulating Glutaminolysis in Colorectal Carcinoma Cells.A novel in situ probe for oxygen uptake rate measurement in mammalian cell cultures.Growth, metabolic activity, and productivity of immobilized and freely suspended CHO cells in perfusion culture.Differential effect of culture temperature and specific growth rate on CHO cell behavior in chemostat culture.High-throughput nucleoside phosphate monitoring in mammalian cell fed-batch cultivation using quantitative matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.Cyclin and DNA distributed cell cycle model for GS-NS0 cells.Endoplasmic Reticulum-Associated rht-PA Processing in CHO Cells: Influence of Mild Hypothermia and Specific Growth Rates in Batch and Chemostat CulturesEffect of Temperature Downshift on the Transcriptomic Responses of Chinese Hamster Ovary Cells Using Recombinant Human Tissue Plasminogen Activator Production Culture.Optimization of bioprocess conditions improves production of a CHO cell-derived, bioengineered heparinDifferential response in downstream processing of CHO cells grown under mild hypothermic conditions.The effects of culture conditions on the glycosylation of secreted human placental alkaline phosphatase produced in Chinese hamster ovary cells.The effects of microcarrier culture on recombinant CHO cells under biphasic hypothermic culture conditions.Current state and perspectives on erythropoietin production.Glycosylation: impact, control and improvement during therapeutic protein production.Quantitative intracellular flux modeling and applications in biotherapeutic development and production using CHO cell cultures.Screening and assessment of performance and molecule quality attributes of industrial cell lines across different fed-batch systems.Insights into pH-induced metabolic switch by flux balance analysis.Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation.Development of small scale cell culture models for screening poloxamer 188 lot-to-lot variation.Effects of glutamine and asparagine on recombinant antibody production using CHO-GS cell lines.Perfusion seed cultures improve biopharmaceutical fed-batch production capacity and product quality.High-throughput miniaturized bioreactors for cell culture process development: reproducibility, scalability, and control.The translation of cell-based therapies: clinical landscape and manufacturing challenges.Effect of culture pH on recombinant antibody production by a new human cell line, F2N78, grown in suspension at 33.0 °C and 37.0 °C.Advances and drawbacks of the adaptation to serum-free culture of CHO-K1 cells for monoclonal antibody production.Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis.The use of a stringent selection system allows the identification of DNA elements that augment gene expression.Advanced microscale bioreactor system: a representative scale-down model for bench-top bioreactors.Metabolic Control in Mammalian Fed-Batch Cell Cultures for Reduced Lactic Acid Accumulation and Improved Process RobustnessInvestigation of the interactions of critical scale-up parameters (pH, pO2 and pCO2) on CHO batch performance and critical quality attributes.Endogenous microRNA clusters outperform chimeric sequence clusters in Chinese hamster ovary cellsIn situ Raman spectroscopy for simultaneous monitoring of multiple process parameters in mammalian cell culture bioreactors.Role of iron and sodium citrate in animal protein-free CHO cell culture medium on cell growth and monoclonal antibody production.Hypoxia influences protein transport and epigenetic repression of CHO cell cultures in shake flasks.Modeling of cell culture damage and recovery leads to increased antibody and biomass productivity in CHO cell cultures.A practical approach in bioreactor scale-up and process transfer using a combination of constant P/V and vvm as the criterion.A robust feeding strategy to maintain set-point glucose in mammalian fed-batch cultures when input parameters have a large error.
P2860
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P2860
Process parameter shifting: Part I. Effect of DOT, pH, and temperature on the performance of Epo-Fc expressing CHO cells cultivated in controlled batch bioreactors.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Process parameter shifting: Pa ...... controlled batch bioreactors.
@en
type
label
Process parameter shifting: Pa ...... controlled batch bioreactors.
@en
prefLabel
Process parameter shifting: Pa ...... controlled batch bioreactors.
@en
P2093
P50
P356
P1476
Process parameter shifting: Pa ...... controlled batch bioreactors.
@en
P2093
Christine Lattenmayer
Dethardt Müller
Evelyn Trummer
Hermann Katinger
Katharina Fauland
Kornelia Schriebl
Robert Weik
Silke Seidinger
P304
P356
10.1002/BIT.21013
P577
2006-08-01T00:00:00Z