S-Adenosyl-L-methionine-dependent macromolecule methyltransferases: potential targets for the design of chemotherapeutic agents.
about
Structure of Escherichia coli 5'-methylthioadenosine/ S-adenosylhomocysteine nucleosidase inhibitor complexes provide insight into the conformational changes required for substrate binding and catalysisSmall Molecule Inhibitors That Selectively Block Dengue Virus MethyltransferaseCrystal Structures of the Helicobacter pylori MTAN Enzyme Reveal Specific Interactions between S -Adenosylhomocysteine and the 5′-Alkylthio Binding SubsiteA novel methyltransferase catalyzes the methyl esterification of trans-aconitate in Escherichia coliVaccinia virus inhibitors as a paradigm for the chemotherapy of poxvirus infectionsEffect of analogues of 5'-methylthioadenosine on cellular metabolism. Inactivation of S-adenosylhomocysteine hydrolase by 5'-isobutylthioadenosineHuman S-adenosylhomocysteine hydrolase: common gene sequence variation and functional genomic characterization.Sinefungin, a natural nucleoside analogue of S-adenosylmethionine, inhibits Streptococcus pneumoniae biofilm growth.Methylthioadenosine reprograms macrophage activation through adenosine receptor stimulationBgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice.Evaluation of Adamantane Derivatives as Inhibitors of Dengue Virus mRNA Cap Methyltransferase by Docking and Molecular Dynamics Simulations.Elaboration of a fragment library hit produces potent and selective aspartate semialdehyde dehydrogenase inhibitors.Differential inhibition of nerve growth factor and epidermal growth factor effects on the PC12 pheochromocytoma line.Expression of the cloned coliphage T3 S-adenosylmethionine hydrolase gene inhibits DNA methylation and polyamine biosynthesis in Escherichia coli.A survey of antiviral drugs for bioweapons.Inhibition of sterol transmethylation by S-adenosylhomocysteine analogs.From actually toxic to highly specific--novel drugs against poxviruses.Structure and inhibition of a quorum sensing target from Streptococcus pneumoniaeMethylation of high molecular weight fibroblast growth factor-2 determines post-translational increases in molecular weight and affects its intracellular distribution.Methylation inhibitors can increase the rate of cytosine deamination by (cytosine-5)-DNA methyltransferase.An approach to the total synthesis of sinefungin.Expanding the chemical scope of RNA:methyltransferases to site-specific alkynylation of RNA for click labeling.Relative effects of S-adenosylmethionine depletion on nucleic acid methylation and polyamine biosynthesisA universal competitive fluorescence polarization activity assay for S-adenosylmethionine utilizing methyltransferasesDecrease in S-adenosylmethionine synthesis by 6-mercaptopurine and methylmercaptopurine ribonucleoside in Molt F4 human malignant lymphoblasts.Inhibition of lymphocyte-mediated cytolysis and cyclic AMP phosphodiesterase by erythro-9-(2-hydroxy-3-nonyl)adenine.Affinity purification of 5-methylthioribose kinase and 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Klebsiella pneumoniae [corrected].John Montgomery's legacy: carbocyclic adenosine analogues as SAH hydrolase inhibitors with broad-spectrum antiviral activity.Direct Detection of Products from S-Adenosylmethionine-Dependent Enzymes Using a Competitive Fluorescence Polarization Assay.A novel mechanism-based inhibitor (6'-bromo-5', 6'-didehydro-6'-deoxy-6'-fluorohomoadenosine) that covalently modifies human placental S-adenosylhomocysteine hydrolase.Does phospholipid methylation play a role in the primary mechanism of action of nerve growth factor?
P2860
Q27640206-23D670D8-C361-4CBE-90B6-627B3D9015FEQ27666321-38FD7798-97E7-47BF-812E-776B0FDA1DD5Q27675111-19FFBFCB-7753-4A13-A736-0DE2129C5937Q28142862-B33B1D5D-B770-415A-B316-8EAACC8AE23AQ28362129-69CD697D-A314-48B8-B1CF-56FBB8A2954AQ28366549-D20CDA58-5E59-408F-A2FF-0DAD3C635C1AQ33726940-0B2F22C3-D58D-4F88-8C26-D0ED5F8D8E63Q33891303-DBB320EC-500F-4563-97DE-4413D76C0752Q34035329-387A1F11-47B9-4930-8D49-88DAF6A0EFB9Q34601829-BFBCD9D8-E171-468C-B751-25737D8F68ACQ36092127-3E3E31D3-63AF-4E64-9482-515F2778C479Q36148093-47584E07-DA9E-49A5-85EB-95580F10B44CQ36210059-9F583E87-3B29-48D6-879F-D14B40A59282Q36240765-9280F14B-FD55-4BD5-9A46-F3F35953C808Q36295162-58A0E898-4F7D-4352-94CB-D023412F4F36Q36322634-56163C10-CC11-45DF-9710-87A6AEE1314CQ36708435-7EB89858-4E92-4E5C-BDBE-6A52DAA79970Q36840500-74786C9A-FB16-40CB-B999-D361E07668EBQ37381980-35647529-4BB2-4B4B-AC40-78039F16D2DCQ39717174-C8971670-C250-4053-8BEC-78A4B86B46CFQ40496786-DB3483BD-901A-47CF-BD8D-C65330E8E41CQ41830946-D8191537-E1DA-4610-9966-42194422A276Q41864656-F041F76E-2930-457D-BB4C-516FA83D100CQ42203930-604619CB-A8F9-4DAF-9D6B-9C1CA20B90E0Q42285570-11A753A6-1F23-447A-BC1D-BA583D2968C1Q42452659-B65E93E1-F6F8-478A-936B-3A7E29CAB77CQ42633628-48BAE315-7B06-491F-9350-6C186540226BQ44091038-CBF9DE12-8C69-4DCD-9EC1-520472061542Q47221064-1C39D8FC-4B59-49D3-A1C7-3B7C3F6B3803Q47859863-5BFF3921-5F2F-42A1-A445-98C209206FF7Q54236748-A3D173C5-1C40-4A17-8D6A-138430AEB2AC
P2860
S-Adenosyl-L-methionine-dependent macromolecule methyltransferases: potential targets for the design of chemotherapeutic agents.
description
1980 nî lūn-bûn
@nan
1980年の論文
@ja
1980年論文
@yue
1980年論文
@zh-hant
1980年論文
@zh-hk
1980年論文
@zh-mo
1980年論文
@zh-tw
1980年论文
@wuu
1980年论文
@zh
1980年论文
@zh-cn
name
S-Adenosyl-L-methionine-depend ...... gn of chemotherapeutic agents.
@en
type
label
S-Adenosyl-L-methionine-depend ...... gn of chemotherapeutic agents.
@en
prefLabel
S-Adenosyl-L-methionine-depend ...... gn of chemotherapeutic agents.
@en
P356
P1476
S-Adenosyl-L-methionine-depend ...... gn of chemotherapeutic agents.
@en
P2093
Borchardt RT
P304
P356
10.1021/JM00178A001
P407
P577
1980-04-01T00:00:00Z