Activation of mitogen-activated protein kinase in estrogen receptor alpha-positive breast cancer cells in vitro induces an in vivo molecular phenotype of estrogen receptor alpha-negative human breast tumors.
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DART: Denoising Algorithm based on Relevance network Topology improves molecular pathway activity inferenceNF-kappaB activation in inflammatory breast cancer is associated with oestrogen receptor downregulation, secondary to EGFR and/or ErbB2 overexpression and MAPK hyperactivationMicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancerLoss of Rho GDIα and resistance to tamoxifen via effects on estrogen receptor αUsing large-scale molecular data sets to improve breast cancer treatment.Multiple platform assessment of the EGF dependent transcriptome by microarray and deep tag sequencing analysisA gene transcription signature associated with hormone independence in a subset of both breast and prostate cancersTranscriptional profiling of non-small cell lung cancer cells with activating EGFR somatic mutations.Multiple oncogenic pathway signatures show coordinate expression patterns in human prostate tumorsKnowledge driven decomposition of tumor expression profilesNovel roles for ERK5 and cofilin as critical mediators linking ERα-driven transcription, actin reorganization, and invasiveness in breast cancer.Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor α signalling and results in tamoxifen insensitive proliferationImproved prognostic classification of breast cancer defined by antagonistic activation patterns of immune response pathway modulesExpression of Long-chain Fatty Acyl-CoA Synthetase 4 in Breast and Prostate Cancers Is Associated with Sex Steroid Hormone Receptor Negativity.Apoptosis inhibitor-5 overexpression is associated with tumor progression and poor prognosis in patients with cervical cancerProteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer.GABA(A) receptor pi (GABRP) stimulates basal-like breast cancer cell migration through activation of extracellular-regulated kinase 1/2 (ERK1/2).Microarray phosphatome profiling of breast cancer patients unveils a complex phosphatase regulatory role of the MAPK and PI3K pathways in estrogen receptor-negative breast cancersmiR-125b can enhance skin tumor initiation and promote malignant progression by repressing differentiation and prolonging cell survivalHigh throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer.High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy.Epigenetic Reactivation of Estrogen Receptor: Promising Tools for Restoring Response to Endocrine Therapy.Transfer of clinically relevant gene expression signatures in breast cancer: from Affymetrix microarray to Illumina RNA-Sequencing technology.MEK5/ERK5 signaling suppresses estrogen receptor expression and promotes hormone-independent tumorigenesisA urokinase receptor-Bim signaling axis emerges during EGFR inhibitor resistance in mutant EGFR glioblastoma.The role of miR-206 in the epidermal growth factor (EGF) induced repression of estrogen receptor-alpha (ERalpha) signaling and a luminal phenotype in MCF-7 breast cancer cells.Can systems biology understand pathway activation? Gene expression signatures as surrogate markers for understanding the complexity of pathway activation.Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase.The forkhead transcription factor FOXM1 promotes endocrine resistance and invasiveness in estrogen receptor-positive breast cancer by expansion of stem-like cancer cellsCorrelation of GREB1 mRNA with protein expression in breast cancer: validation of a novel GREB1 monoclonal antibody.Mechanisms of Gefitinib-mediated reversal of tamoxifen resistance in MCF-7 breast cancer cells by inducing ERα re-expression.Adaptive changes result in activation of alternate signaling pathways and acquisition of resistance to aromatase inhibitorsTamoxifen downregulation of miR-451 increases 14-3-3ζ and promotes breast cancer cell survival and endocrine resistance.Cadmium and proliferation in human uterine leiomyoma cells: evidence of a role for EGFR/MAPK pathways but not classical estrogen receptor pathwaysLrig1 is an estrogen-regulated growth suppressor and correlates with longer relapse-free survival in ERα-positive breast cancer.A functional landscape of resistance to ALK inhibition in lung cancer.MAPK7 Regulates EMT Features and Modulates the Generation of CTCs.Macrophage-elicited loss of estrogen receptor-α in breast cancer cells via involvement of MAPK and c-Jun at the ESR1 genomic locus.ERRγ target genes are poor prognostic factors in Tamoxifen-treated breast cancer.p38γ mitogen-activated protein kinase (MAPK) confers breast cancer hormone sensitivity by switching estrogen receptor (ER) signaling from classical to nonclassical pathway via stimulating ER phosphorylation and c-Jun transcription.
P2860
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P2860
Activation of mitogen-activated protein kinase in estrogen receptor alpha-positive breast cancer cells in vitro induces an in vivo molecular phenotype of estrogen receptor alpha-negative human breast tumors.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Activation of mitogen-activate ...... -negative human breast tumors.
@en
type
label
Activation of mitogen-activate ...... -negative human breast tumors.
@en
prefLabel
Activation of mitogen-activate ...... -negative human breast tumors.
@en
P2093
P1433
P1476
Activation of mitogen-activate ...... -negative human breast tumors.
@en
P2093
Amy M Hilger
Arul M Chinnaiyan
Chad J Creighton
Dorraya El-Ashry
James M Rae
Shalini Murthy
P304
P356
10.1158/0008-5472.CAN-05-4363
P407
P577
2006-04-01T00:00:00Z