Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state.
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Mutator pathways unleashed by epigenetic silencing in human cancerTargeting histone methyltransferases and demethylases in clinical trials for cancer therapyActive DNA demethylation in post-mitotic neurons: a reason for optimismDNA methylation and microRNAs in cancerEpigenetics meets radiation biology as a new approach in cancer treatmentStructural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9aMPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9aThe epigenomics of cancerThe role of cadmium and nickel in estrogen receptor signaling and breast cancer: metalloestrogens or not?Role of CTCF protein in regulating FMR1 locus transcriptionChromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activationAn HMM approach to genome-wide identification of differential histone modification sites from ChIP-seq data.A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencingAn integrative genomic and epigenomic approach for the study of transcriptional regulationPcG proteins, DNA methylation, and gene repression by chromatin looping.Aberrant epigenetic silencing is triggered by a transient reduction in gene expressionCDKN1C (p57) is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast cancer cellsEpigenetic mechanisms regulate MHC and antigen processing molecules in human embryonic and induced pluripotent stem cellsEpigenetic reprogramming modulates malignant properties of human liver cancer.Modulation of microRNA expression in human lung cancer cells by the G9a histone methyltransferase inhibitor BIX01294.Epigenetic Targeting of Transforming Growth Factor β Receptor II and Implications for Cancer TherapyTranscriptional repressive H3K9 and H3K27 methylations contribute to DNMT1-mediated DNA methylation recoveryPromoter hypomethylation of EpCAM-regulated bone morphogenetic protein gene family in recurrent endometrial cancerAcute dyskerin depletion triggers cellular senescence and renders osteosarcoma cells resistant to genotoxic stress-induced apoptosis.H3K27 trimethylation is an early epigenetic event of p16INK4a silencing for regaining tumorigenesis in fusion reprogrammed hepatoma cellsA new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation.Gain of DNA methylation is enhanced in the absence of CTCF at the human retinoblastoma gene promoter.Silencing of the DNA mismatch repair gene MLH1 induced by hypoxic stress in a pathway dependent on the histone demethylase LSD1Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.Epigenetic regulation of the human p53 gene promoter by the CTCF transcription factor in transformed cell lines.Chromatin remodeling is required for gene reactivation after decitabine-mediated DNA hypomethylation.Fibronectin affects transient MMP2 gene expression through DNA demethylation changes in non-invasive breast cancer cell lines.Current limitations and future opportunities for epigenetic therapies.Re-expression of methylation-induced tumor suppressor gene silencing is associated with the state of histone modification in gastric cancer cell lines.Wnt signaling in cancerEpigenetic therapy of acute myeloid leukemia using 5-aza-2'-deoxycytidine (decitabine) in combination with inhibitors of histone methylation and deacetylation.An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis.Cell specific CD44 expression in breast cancer requires the interaction of AP-1 and NFκB with a novel cis-element.Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spatial organization in the nucleus.
P2860
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P2860
Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Silenced tumor suppressor gene ...... y euchromatic chromatin state.
@en
type
label
Silenced tumor suppressor gene ...... y euchromatic chromatin state.
@en
prefLabel
Silenced tumor suppressor gene ...... y euchromatic chromatin state.
@en
P2093
P1433
P1476
Silenced tumor suppressor gene ...... y euchromatic chromatin state.
@en
P2093
Eriko Greene
Jill A Fahrner
Joost Martens
Kelly M McGarvey
Stephen B Baylin
Thomas Jenuwein
P304
P356
10.1158/0008-5472.CAN-05-2481
P407
P577
2006-04-01T00:00:00Z