Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells.
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Minnelide: a novel therapeutic that promotes apoptosis in non-small cell lung carcinoma in vivoTriptolide downregulates human GD3 synthase (hST8Sia I) gene expression in SK-MEL-2 human melanoma cellsTriptolide induces growth inhibition and apoptosis of human laryngocarcinoma cells by enhancing p53 activities and suppressing E6-mediated p53 degradationMerging traditional Chinese medicine with modern drug discovery technologies to find novel drugs and functional foodsTriptolide induces cell-cycle arrest and apoptosis of human multiple myeloma cells in vitro via altering expression of histone demethylase LSD1 and JMJD2B.Effects of triptolide on RIZ1 expression, proliferation, and apoptosis in multiple myeloma U266 cellsCan cytoplasmic nucleophosmin be detected by immunocytochemical staining of cell smears in acute myeloid leukemia?Preclinical antileukemic activity, toxicology, toxicokinetics and formulation development of triptolide derivative MRx102.Triptolide (TPL) inhibits global transcription by inducing proteasome-dependent degradation of RNA polymerase II (Pol II).Triptolide inhibits proliferation and migration of colon cancer cells by inhibition of cell cycle regulators and cytokine receptors.Antagonist effect of triptolide on AKT activation by truncated retinoid X receptor-alphaTriptolide inhibits human immunodeficiency virus type 1 replication by promoting proteasomal degradation of Tat proteinHsp90 inhibitor BIIB021 enhances triptolide-induced apoptosis of human T-cell acute lymphoblastic leukemia cells in vitro mainly by disrupting p53-MDM2 balanceAnti-cancer natural products isolated from chinese medicinal herbsTriptolide induces apoptotic cell death of human cholangiocarcinoma cells through inhibition of myeloid cell leukemia-1.Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway.Genome-wide association analysis identified splicing single nucleotide polymorphism in CFLAR predictive of triptolide chemo-sensitivity.Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney diseaseTriptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5.Current therapeutic strategies for acute myeloid leukaemia.Triptolide inhibits MDM2 and induces apoptosis in acute lymphoblastic leukemia cells through a p53-independent pathway.Activation of apoptosis signaling eliminates CD34+ progenitor cells in blast crisis CML independent of response to tyrosine kinase inhibitors.MRx102, a triptolide derivative, has potent antileukemic activity in vitro and in a murine model of AMLTriptolide-induced transcriptional arrest is associated with changes in nuclear substructureApoptosis of human pancreatic cancer cells induced by Triptolide.Triptolide-mediated inhibition of interferon signaling enhances vesicular stomatitis virus-based oncolysis.Endogenous knockdown of survivin improves chemotherapeutic response in ALL models.Triptolide induces cell death independent of cellular responses to imatinib in blast crisis chronic myelogenous leukemia cells including quiescent CD34+ primitive progenitor cells.A new dawn for the use of traditional Chinese medicine in cancer therapy.Triptolide induces apoptosis in human leukemia cells through caspase-3-mediated ROCK1 activation and MLC phosphorylation.Overcoming glucocorticoid resistance: a new pathway from an ancient Chinese medicine?Anti-cancer and Sensibilisation Effect of Triptolide on Human Epithelial Ovarian Cancer.Low dose triptolide reverses chemoresistance in adult acute lymphoblastic leukemia cells via reactive oxygen species generation and DNA damage response disruption.Apoptosis in leukemias: regulation and therapeutic targeting.Triptolide inhibits the proliferation of cells from lymphocytic leukemic cell lines in association with downregulation of NF-κB activity and miR-16-1*.Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms.Anticancer drugs from traditional toxic Chinese medicines.Integrative oncology meets immunotherapy: new prospects for combination therapy grounded in Eastern medical knowledge.Traditional Chinese medicine: a treasured natural resource of anticancer drug research and development.Recent advances in the identification of Tat-mediated transactivation inhibitors: progressing toward a functional cure of HIV.
P2860
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P2860
Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Triptolide induces caspase-dep ...... ial pathway in leukemic cells.
@en
type
label
Triptolide induces caspase-dep ...... ial pathway in leukemic cells.
@en
prefLabel
Triptolide induces caspase-dep ...... ial pathway in leukemic cells.
@en
P2093
P2860
P1433
P1476
Triptolide induces caspase-dep ...... ial pathway in leukemic cells.
@en
P2093
Bing Z Carter
David Harris
Duncan H Mak
Randall L Evans
Teresa McQueen
Wendy D Schober
P2860
P304
P356
10.1182/BLOOD-2005-09-3898
P407
P577
2006-03-23T00:00:00Z