Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies.
about
The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) familyGenetics of valvular heart diseaseGalnt1 is required for normal heart valve development and cardiac functionVersican and the regulation of cell phenotype in diseaseSystems biology-opportunities and challenges: the application of proteomics to study the cardiovascular extracellular matrixEndothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndromeBiosynthesis and expression of a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats-15: a novel versican-cleaving proteoglycanaseThe multiple, complex roles of versican and its proteolytic turnover by ADAMTS proteases during embryogenesis.Isolation and purification of versican and analysis of versican proteolysis.A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression.Determinants of versican-V1 proteoglycan processing by the metalloproteinase ADAMTS5Genomic scan reveals loci under altitude adaptation in Tibetan and Dahe pigs.Genome-wide association study of gene by smoking interactions in coronary artery calcification.Imbalanced expression of Vcan mRNA splice form proteins alters heart morphology and cellular protein profiles.The evolutionary conservation of the A Disintegrin-like and Metalloproteinase domain with Thrombospondin-1 motif metzincins across vertebrate species and their expression in teleost zebrafishPericellular versican regulates the fibroblast-myofibroblast transition: a role for ADAMTS5 protease-mediated proteolysisLoss of Gata5 in mice leads to bicuspid aortic valve.Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease.ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and RotationMaladaptive matrix remodeling and regional biomechanical dysfunction in a mouse model of aortic valve disease.Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferationEndocardial Brg1 disruption illustrates the developmental origins of semilunar valve disease.Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults.Emerging Roles of ADAMTSs in Angiogenesis and Cancer.Impaired ADAMTS9 secretion: A potential mechanism for eye defects in Peters Plus Syndrome.Cadherin-11 expression patterns in heart valves associate with key functions during embryonic cushion formation, valve maturation and calcification.Heart valve structure and function in development and diseaseMolecular and developmental mechanisms of congenital heart valve disease.Extracellular matrix and heart development.Extracellular metalloproteinases in neural crest development and craniofacial morphogenesis.Review of molecular and mechanical interactions in the aortic valve and aorta: implications for the shared pathogenesis of aortic valve disease and aortopathy.Functional analysis of candidate genes in 2q13 deletion syndrome implicates FBLN7 and TMEM87B deficiency in congenital heart defects and FBLN7 in craniofacial malformations.Molecular regulation of cardiomyocyte differentiation.Comparative transcriptome profiling in human bicuspid aortic valve disease using RNA sequencing.Genetic and biochemical evidence that gastrulation defects in Pofut2 mutants result from defects in ADAMTS9 secretion.Extracellular matrix and the myeloid-in-myeloma compartment: balancing tolerogenic and immunogenic inflammation in the myeloma niche.Hyaluronidase 2 Deficiency Causes Increased Mesenchymal Cells, Congenital Heart Defects, and Heart Failure.Provisional matrix: A role for versican and hyaluronan.ADAMTS9 is a functional tumor suppressor through inhibiting AKT/mTOR pathway and associated with poor survival in gastric cancer.Activation of Mouse Cumulus-Oocyte Complex Maturation In Vitro Through EGF-Like Activity of Versican.
P2860
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P2860
Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Reduced versican cleavage due ...... cardiac and aortic anomalies.
@en
type
label
Reduced versican cleavage due ...... cardiac and aortic anomalies.
@en
prefLabel
Reduced versican cleavage due ...... cardiac and aortic anomalies.
@en
P2093
P2860
P1433
P1476
Reduced versican cleavage due ...... cardiac and aortic anomalies.
@en
P2093
Andy Wessels
Christine B Kern
Courtney M Nelson
Danielle Geeting
Donald R Menick
Ebony Alston
Jessica McGarity
Laura J Dixon
Suneel S Apte
W Scott Argraves
P2860
P304
P356
10.1016/J.MATBIO.2010.01.005
P577
2010-01-22T00:00:00Z