A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR).
about
Cell adhesion receptor GPR133 couples to Gs proteinDiscovery and Development of Small Molecule Allosteric Modulators of Glycoprotein Hormone ReceptorsTSH Receptor Signaling Abrogation by a Novel Small MoleculeUnraveling the structure and function of G protein-coupled receptors through NMR spectroscopy.Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at WorkComputing highly correlated positions using mutual information and graph theory for G protein-coupled receptors.The pilot phase of the NIH Chemical Genomics Center.Human TSH receptor ligands as pharmacological probes with potential clinical applicationThe DREAM protein is associated with thyroid enlargement and nodular development.β-Arrestin-1 mediates thyrotropin-enhanced osteoblast differentiationA new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptorNew small molecule agonists to the thyrotropin receptor.Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor.Defining structural and functional dimensions of the extracellular thyrotropin receptor region.Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor.Targeting the thyroid-stimulating hormone receptor with small molecule ligands and antibodiesThe Synthesis and Evaluation of Dihydroquinazolin-4-ones and Quinazolin-4-ones as Thyroid Stimulating Hormone Receptor Agonists.The "TSH Receptor Glo Assay" - A High-Throughput Detection System for Thyroid Stimulation.The thyrotropin receptor hinge region as a surrogate ligand: identification of loci contributing to the coupling of thyrotropin binding and receptor activationUpdate in TSH receptor agonists and antagonistsAsp330 and Tyr331 in the C-terminal cysteine-rich region of the luteinizing hormone receptor are key residues in hormone-induced receptor activation.Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns.A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidismRearrangement of the Extracellular Domain/Extracellular Loop 1 Interface Is Critical for Thyrotropin Receptor ActivationIncreased plasma membrane expression of human follicle-stimulating hormone receptor by a small molecule thienopyr(im)idine.Novel insights on thyroid-stimulating hormone receptor signal transduction.Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice.Allosteric modulators hit the TSH receptor.Molecular sampling of the allosteric binding pocket of the TSH receptor provides discriminative pharmacophores for antagonist and agonistsTSHR as a therapeutic target in Graves' disease.Expanding the Role of Thyroid-Stimulating Hormone in Skeletal Physiology.Contacts between extracellular loop two and transmembrane helix six determine basal activity of the thyroid-stimulating hormone receptor.Pharmacoperones for Misfolded Gonadotropin Receptors.New advances in understanding thyroid-associated ophthalmopathy and the potential role for insulin-like growth factor-I receptor.
P2860
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P2860
A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR).
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
A low molecular weight agonist ...... gonadotropin receptor (LHCGR).
@en
type
label
A low molecular weight agonist ...... gonadotropin receptor (LHCGR).
@en
prefLabel
A low molecular weight agonist ...... gonadotropin receptor (LHCGR).
@en
P2093
P2860
P356
P1476
A low molecular weight agonist ...... gonadotropin receptor (LHCGR).
@en
P2093
Anny-Odile Colson
Bruce M Raaka
Craig J Thomas
Gerd Krause
Gunnar Kleinau
Holger Jäschke
Jian-Kang Jiang
Marvin C Gershengorn
Ralf Paschke
Susanna Moore
P2860
P304
P356
10.1074/JBC.C600014200
P407
P577
2006-02-16T00:00:00Z