O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells.
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Understanding glioma stem cells: rationale, clinical relevance and therapeutic strategiesTranscriptional regulation of human DNA repair genes following genotoxic stress: trigger mechanisms, inducible responses and genotoxic adaptationThe role of p53 in cancer drug resistance and targeted chemotherapyTransfection of a human glioblastoma cell line with liver-type glutaminase (LGA) down-regulates the expression of DNA-repair gene MGMT and sensitizes the cells to alkylating agentsA nanoparticle carrying the p53 gene targets tumors including cancer stem cells, sensitizes glioblastoma to chemotherapy and improves survival.Role of Nitric Oxide in Glioblastoma Therapy: Another Step to Resolve the Terrible Puzzle ?DNA ligase IV as a new molecular target for temozolomideFirst-line temozolomide chemotherapy in progressive low-grade astrocytomas after radiotherapy: molecular characteristics in relation to response.Metabolic targeting of EGFRvIII/PDK1 axis in temozolomide resistant glioblastoma.Pathologies associated with the p53 response.Absence of the MGMT protein as well as methylation of the MGMT promoter predict the sensitivity for temozolomideRad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs.Molecular targeting of TRF2 suppresses the growth and tumorigenesis of glioblastoma stem cells.FasL and FADD delivery by a glioma-specific and cell cycle-dependent HSV-1 amplicon virus enhanced apoptosis in primary human brain tumors.Metabolic Effects of Known and Novel HDAC and SIRT Inhibitors in Glioblastomas Independently or Combined with TemozolomideActivation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition.Prognostic and predictive markers in recurrent high grade glioma; results from the BR12 randomised trialSurvival and death strategies in glioma cells: autophagy, senescence and apoptosis triggered by a single type of temozolomide-induced DNA damage.Resveratrol abrogates the temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the temozolomide-induced senescence in glioma cells.Glioma cell death induced by irradiation or alkylating agent chemotherapy is independent of the intrinsic ceramide pathway.APO010, a synthetic hexameric CD95 ligand, induces human glioma cell death in vitro and in vivo.Downregulation of BRCA1-BRCA2-containing complex subunit 3 sensitizes glioma cells to temozolomideEarly assessment of the efficacy of temozolomide chemotherapy in experimental glioblastoma using [18F]FLT-PET imaging.Rad51 inhibition is an effective means of targeting DNA repair in glioma models and CD133+ tumor-derived cellsMJ-66 induces malignant glioma cells G2/M phase arrest and mitotic catastrophe through regulation of cyclin B1/Cdk1 complex.Leveraging metabolomics to assess the next generation of temozolomide-based therapeutic approaches for glioblastomasp53 upregulated modulator of apoptosis sensitizes drug-resistant U251 glioblastoma stem cells to temozolomide through enhanced apoptosisChemoresistance of glioblastoma cancer stem cells--much more complex than expected.Current trends in targeted therapies for glioblastoma multiformep53 regulates the mevalonate pathway in human glioblastoma multiforme.Fermented mistletoe extract as a multimodal antitumoral agent in gliomas.Impact of temozolomide on immune response during malignant glioma chemotherapyMechanisms of chemoresistance to alkylating agents in malignant glioma.Evaluation of poly (ADP-ribose) polymerase inhibitor ABT-888 combined with radiotherapy and temozolomide in glioblastoma.The role of glioma stem cells in chemotherapy resistance and glioblastoma multiforme recurrence.Combining bevacizumab with temozolomide increases the antitumor efficacy of temozolomide in a human glioblastoma orthotopic xenograft model.Outpatient chemotherapy plus radiotherapy in sarcomas: improving cancer control with radiosensitizing agents.Suppression of the Eag1 potassium channel sensitizes glioblastoma cells to injury caused by temozolomideYB-1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells.Glioblastoma multiforme therapy and mechanisms of resistance.
P2860
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P2860
O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
O6-methylguanine DNA methyltra ...... human malignant glioma cells.
@en
type
label
O6-methylguanine DNA methyltra ...... human malignant glioma cells.
@en
prefLabel
O6-methylguanine DNA methyltra ...... human malignant glioma cells.
@en
P2093
P50
P1476
O6-methylguanine DNA methyltra ...... human malignant glioma cells.
@en
P2093
Andrea Klumpp
Bernd Kaina
Georg Nagel
Mirjam Hermisson
P304
P356
10.1111/J.1471-4159.2005.03583.X
P407
P577
2006-01-09T00:00:00Z