Gelsolin-related amyloidosis. Identification of the amyloid protein in Finnish hereditary amyloidosis as a fragment of variant gelsolin.
about
The 8 and 5 kDa fragments of plasma gelsolin form amyloid fibrils by a nucleated polymerization mechanism, while the 68 kDa fragment is not amyloidogenicSecretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteinsApolipoprotein AI mutation Arg-60 causes autosomal dominant amyloidosisMedin: an integral fragment of aortic smooth muscle cell-produced lactadherin forms the most common human amyloidCa2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolinYersinia effector protein (YopO)-mediated phosphorylation of host gelsolin causes calcium-independent activation leading to disruption of actin dynamics.Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathiesFurin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca(2+) stabilizationMetalloendoprotease cleavage triggers gelsolin amyloidogenesisDanish type gelsolin related amyloidosis: 654G-T mutation is associated with a disease pathogenetically and clinically similar to that caused by the 654G-A mutation (familial amyloidosis of the Finnish type).Formation of gelsolin amyloid fibrils in the rough endoplasmic reticulum of skeletal muscle in the gelsolin mouse model of inclusion body myositis: comparative analysis to human sporadic inclusion body myositisProtein post-translational modifications and misfolding: new concepts in heart failure.Synthetic peptides homologous to prion protein residues 106-147 form amyloid-like fibrils in vitro.Heparin accelerates gelsolin amyloidogenesis.Amyloidogenesis of natively unfolded proteins.Immunohistochemical analysis of lattice corneal dystrophies types I and II.Gelsolin amyloidosis: genetics, biochemistry, pathology and possible strategies for therapeutic intervention.A perspective on mechanisms of protein tetramer formation.Ocular surface development and gene expression.A general strategy for the bacterial expression of amyloidogenic peptides using BCL-XL-1/2 fusions.Calcium-dependent conformational stability of modules 1 and 2 of human gelsolin.Heparin binds 8 kDa gelsolin cross-β-sheet oligomers and accelerates amyloidogenesis by hastening fibril extension.Respiratory chain enzyme deficiency induces mitochondrial location of actin-binding gelsolin to modulate the oligomerization of VDAC complexes and cell survival.Clinical characteristics and SAP scintigraphic findings in 10 patients with AGel amyloidosis.Casein related amyloid, characterization of a new and unique amyloid protein isolated from bovine corpora amylacea.Amyloid precursor proteins form ordered fibrilsPostmortem pathological findings in a Japanese patient with familial amyloidosis, Finnish type (FAF)
P2860
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P2860
Gelsolin-related amyloidosis. Identification of the amyloid protein in Finnish hereditary amyloidosis as a fragment of variant gelsolin.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Gelsolin-related amyloidosis. ...... fragment of variant gelsolin.
@en
type
label
Gelsolin-related amyloidosis. ...... fragment of variant gelsolin.
@en
prefLabel
Gelsolin-related amyloidosis. ...... fragment of variant gelsolin.
@en
P2860
P356
P1476
Gelsolin-related amyloidosis. ...... fragment of variant gelsolin.
@en
P2093
P2860
P304
P356
10.1172/JCI115118
P407
P577
1991-04-01T00:00:00Z