Up-regulation of the clusterin gene after proteotoxic stress: implication of HSF1-HSF2 heterocomplexes. - Wikidata - wikimedia - TriplyDB

Up-regulation of the clusterin gene after proteotoxic stress: implication of HSF1-HSF2 heterocomplexes.

Up-regulation of the clusterin gene after proteotoxic stress: implication of HSF1-HSF2 heterocomplexes.

http://www.wikidata.org/entity/Q40342417

about

Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells Clusterin: a key player in cancer chemoresistance and its inhibition Friend or foe? The current epidemiologic evidence on selenium and human cancer risk Non-secreted clusterin isoforms are translated in rare amounts from distinct human mRNA variants and do not affect Bax-mediated apoptosis or the NF-κB signaling pathway Heat-shock factor 2 is a suppressor of prostate cancer invasion.Identification of heat shock factor 1 molecular and cellular targets during embryonic and adult female meiosis Expression of HSF2 decreases in mitosis to enable stress-inducible transcription and cell survival.Heat shock factor 2 is a stress-responsive mediator of neuronal migration defects in models of fetal alcohol syndrome Unraveling complex interplay between heat shock factor 1 and 2 splicing isoforms.Apolipoproteins in the brain: implications for neurological and psychiatric disorders.Evidence for a functional role of the molecular chaperone clusterin in amyloidotic cardiomyopathy.HSFs and regulation of Hsp70.1 (Hspa1b) in oocytes and preimplantation embryos: new insights brought by transgenic and knockout mouse models Clusterin facilitates metastasis by EIF3I/Akt/MMP13 signaling in hepatocellular carcinoma.Clusterin expression can be modulated by changes in TCF1-mediated Wnt signaling.Regulation of clusterin/apolipoprotein J, a functional homologue to the small heat shock proteins, by oxidative stress in ageing and age-related diseases.Heterotrimerization of heat-shock factors 1 and 2 provides a transcriptional switch in response to distinct stimuli.Implication of heat shock factors in tumorigenesis: therapeutical potential.Transcriptional response to stress in the dynamic chromatin environment of cycling and mitotic cells Expression of the protein chaperone, clusterin, in spinal cord cells constitutively and following cellular stress, and upregulation by treatment with Hsp90 inhibitor NeuroD6 genomic signature bridging neuronal differentiation to survival via the molecular chaperone network Clusterin and chemoresistance.Regulation of the members of the mammalian heat shock factor family.Novel aspects of heat shock factors: DNA recognition, chromatin modulation and gene expression.Roles of heat shock factors in gametogenesis and development.Novel targeted agents on the horizon for castration-resistant prostate cancer.The role of clusterin in Alzheimer's disease: pathways, pathogenesis, and therapy.Targeting heat shock proteins in metastatic castration-resistant prostate cancer.Heat shock proteins in hepatocellular carcinoma: Molecular mechanism and therapeutic potential.Metabolic control of the proteotoxic stress response: implications in diabetes mellitus and neurodegenerative disorders.Clusterin as a therapeutic target.The proteasome inhibitor bortezomib is a potent inducer of zinc finger AN1-type domain 2a gene expression: role of heat shock factor 1 (HSF1)-heat shock factor 2 (HSF2) heterocomplexes.Custirsen (OGX-011): a second-generation antisense inhibitor of clusterin in development for the treatment of prostate cancer.Regulation of transcription of hypoxia-inducible factor-1α (HIF-1α) by heat shock factors HSF2 and HSF4.p53-mediated miR-18 repression activates HSF2 for IGF-IIR-dependent myocyte hypertrophy in hypertension-induced heart failure.Anaphase-promoting complex/cyclosome participates in the acute response to protein-damaging stress Targeting the cytoprotective chaperone, clusterin, for treatment of advanced cancer.Secreted clusterin (sCLU) regulates cell proliferation and chemosensitivity to cisplatin by modulating ERK1/2 signals in human osteosarcoma cells.Clustering of heat-shock factors The Role of Heat Shock Factors in Mammalian Spermatogenesis.Reduction in serum clusterin is a potential therapeutic biomarker in patients with castration-resistant prostate cancer treated with custirsen.

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P2860

Up-regulation of the clusterin gene after proteotoxic stress: implication of HSF1-HSF2 heterocomplexes.

http://www.wikidata.org/entity/Q40342417

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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2006年论文

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2006年论文

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name

Up-regulation of the clusterin ...... of HSF1-HSF2 heterocomplexes.

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Up-regulation of the clusterin ...... of HSF1-HSF2 heterocomplexes.

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Up-regulation of the clusterin ...... of HSF1-HSF2 heterocomplexes.

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Biochemical Journal

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Up-regulation of the clusterin ...... n of HSF1-HSF2 heterocomplexes

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P2093

Laure Debure

http://www.w3.org/2001/XMLSchema#string

Pascale le Goff

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Philippe Nizard

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Yves le Dréan

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P2860

Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress

Formation of nuclear stress granules involves HSF2 and coincides with the nucleolar localization of Hsp70

Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease

Intracellular clusterin causes juxtanuclear aggregate formation and mitochondrial alteration

Intracellular trafficking of heat shock factor 2

Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription

Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators

Determination of the consensus binding sequence for the purified embryonic heat shock factor 2.

In vitro activation of heat shock transcription factor DNA-binding by calcium and biochemical conditions that affect protein conformation

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10.1042/BJ20051190

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