The mechanisms and dynamics of (alpha)v(beta)3 integrin clustering in living cells.
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The non-equilibrium thermodynamics and kinetics of focal adhesion dynamicsStructural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectinIntegrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesionsFibronectin Mechanobiology Regulates TumorigenesisMechanochemical regulation of growth cone motilityThe actin-bundling protein L-plastin supports T-cell motility and activationThe talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clusteringCross-Scale Integrin Regulation Organizes ECM and Tissue Topology.Maturation of filopodia shaft adhesions is upregulated by local cycles of lamellipodia advancements and retractionsThe Structure of the N-Terminus of Kindlin-1: A Domain Important for αIIbβ3 Integrin ActivationMembrane Binding of the N-Terminal Ubiquitin-Like Domain of kindlin-2 Is Crucial for Its Regulation of Integrin ActivationA novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesionPIP kinases define PI4,5P₂signaling specificity by association with effectorsIntegrin clustering is driven by mechanical resistance from the glycocalyx and the substrateCrawling cells can close wounds without purse strings or signalingCell adaptive response to extracellular matrix density is controlled by ICAP-1-dependent beta1-integrin affinityKindlin-2 controls bidirectional signaling of integrinsE-cadherin-mediated force transduction signals regulate global cell mechanicsGuidance of Axons by Local Coupling of Retrograde Flow to Point Contact AdhesionsActivation of beta 1 but not beta 3 integrin increases cell traction forces.Focal adhesions are sites of integrin extension.Vinculin controls focal adhesion formation by direct interactions with talin and actin.Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransductionIntegrin-dependent force transmission to the extracellular matrix by α-actinin triggers adhesion maturationExtracellular protein disulfide isomerase regulates ligand-binding activity of αMβ2 integrin and neutrophil recruitment during vascular inflammationLeishmania infection modulates beta-1 integrin activation and alters the kinetics of monocyte spreading over fibronectin.A role for the juxtamembrane cytoplasm in the molecular dynamics of focal adhesionsUrokinase receptor (CD87) clustering in detergent-insoluble adhesion patches leads to cell adhesion independently of integrins.How force might activate talin's vinculin binding sites: SMD reveals a structural mechanism.Quantitative multicolor compositional imaging resolves molecular domains in cell-matrix adhesions.Cooperativity in adhesion cluster formation during initial cell adhesion.Integrin alphaIIbbeta3 activation in Chinese hamster ovary cells and platelets increases clustering rather than affinityNew PI(4,5)P2- and membrane proximal integrin-binding motifs in the talin head control beta3-integrin clustering.Structural and mechanical functions of integrins.Probabilistic modeling and analysis of the effects of extra-cellular matrix density on the sizes, shapes, and locations of integrin clusters in adherent cells.Systems microscopy approaches to understand cancer cell migration and metastasis.Vestigial is required during late-stage muscle differentiation in Drosophila melanogaster embryos.Engineered micromechanical cues affecting human pluripotent stem cell regulations and fate.Transmembrane and cytoplasmic domains in integrin activation and protein-protein interactions (review).The effect of the single substitution of arginine within the RGD tripeptide motif of a modified neurotoxin dendroaspin on its activity of platelet aggregation and cell adhesion.
P2860
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P2860
The mechanisms and dynamics of (alpha)v(beta)3 integrin clustering in living cells.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
The mechanisms and dynamics of (alpha)v(beta)3 integrin clustering in living cells.
@en
type
label
The mechanisms and dynamics of (alpha)v(beta)3 integrin clustering in living cells.
@en
prefLabel
The mechanisms and dynamics of (alpha)v(beta)3 integrin clustering in living cells.
@en
P2093
P2860
P356
P1476
The mechanisms and dynamics of (alpha)v(beta)3 integrin clustering in living cells.
@en
P2093
Beat A Imhof
Bernhard Wehrle-Haller
Caroline Cluzel
Frédéric Saltel
Frédérique Paulhe
Jost Lussi
P2860
P304
P356
10.1083/JCB.200503017
P407
P577
2005-10-01T00:00:00Z