Apoptin nuclear accumulation is modulated by a CRM1-recognized nuclear export signal that is active in normal but not in tumor cells.
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Interaction with PI3-kinase contributes to the cytotoxic activity of apoptinProtein kinases associated with the yeast phosphoproteome.CRM1-mediated Nuclear Export of Dengue Virus RNA Polymerase NS5 Modulates Interleukin-8 Induction and Virus ProductionModeling of molecular interaction between apoptin, BCR-Abl and CrkL--an alternative approach to conventional rational drug designInterferon gamma is recognised by importin alpha/beta: enhanced nuclear localising and transactivation activities of an interferon gamma mimeticCreation of an apoptin-derived peptide that interacts with SH3 domains and inhibits glioma cell migration and invasion.Mapping of apoptin-interaction with BCR-ABL1, and development of apoptin-based targeted therapy.Binding of p110 retinoblastoma protein inhibits nuclear import of simian virus SV40 large tumor antigen.Calmodulin-dependent nuclear import of HMG-box family nuclear factors: importance of the role of SRY in sex reversal.Identification of the NLS and NES motifs of VP2 from chicken anemia virus and the interaction of VP2 with mini-chromosome maintenance protein 3.Mechanism of microtubule-facilitated "fast track" nuclear import.Gallus Heat shock cognate protein 70, a novel binding partner of ApoptinEnhanced tumour cell nuclear targeting in a tumour progression model.Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virusDynein light chain association sequences can facilitate nuclear protein importSelective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes.Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity.A third gyrovirus species in human faecesSecretory Transactivating Transcription-apoptin fusion protein induces apoptosis in hepatocellular carcinoma HepG2 cells.Activation of the Chicken Anemia Virus Apoptin Protein by Chk1/2 Phosphorylation Is Required for Apoptotic Activity and Efficient Viral ReplicationThe flexible loop of the human cytomegalovirus DNA polymerase processivity factor ppUL44 is required for efficient DNA binding and replication in cells.Rhinovirus 16 2A Protease Affects Nuclear Localization of 3CD during InfectionC-terminal region of apoptin affects chicken anemia virus replication and virulence.Naturally occurring, tumor-specific, therapeutic proteins.Mechanisms of Apoptin-induced cell death.MSN anti-cancer nanomedicines: chemotherapy enhancement, overcoming of drug resistance, and metastasis inhibition.Viral genes as oncolytic agents for cancer therapy.DNA damage response signaling triggers nuclear localization of the chicken anemia virus protein Apoptin.Apoptin interacts with and regulates the activity of protein kinase C beta in cancer cells.Selective apoptosis induction in MCF-7 cell line by truncated minimal functional region of Apoptin.Apoptin selectively induces the apoptosis of tumor cells by suppressing the transcription of HSP70.Molecularly modified VP3 (30-121) induces apoptosis in human bladder cancer (EJ) cells but not in normal (3T3) cells.Human Gyrovirus Apoptin shows a similar subcellular distribution pattern and apoptosis induction as the chicken anaemia virus derived VP3/Apoptin.Apoptin induces apoptosis by changing the equilibrium between the stability of TAp73 and ΔNp73 isoforms through ubiquitin ligase PIR2.An AlphaScreen®-based assay for high-throughput screening for specific inhibitors of nuclear import.Akt is transferred to the nucleus of cells treated with apoptin, and it participates in apoptin-induced cell death.Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies.Apoptin nucleocytoplasmic shuttling is required for cell type-specific localization, apoptosis, and recruitment of the anaphase-promoting complex/cyclosome to PML bodies.A truncated apoptin protein variant selectively kills cancer cells.Role of homodimerization of human cytomegalovirus DNA polymerase accessory protein UL44 in origin-dependent DNA replication in cells.
P2860
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P2860
Apoptin nuclear accumulation is modulated by a CRM1-recognized nuclear export signal that is active in normal but not in tumor cells.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Apoptin nuclear accumulation i ...... normal but not in tumor cells.
@en
type
label
Apoptin nuclear accumulation i ...... normal but not in tumor cells.
@en
prefLabel
Apoptin nuclear accumulation i ...... normal but not in tumor cells.
@en
P2093
P1433
P1476
Apoptin nuclear accumulation i ...... normal but not in tumor cells.
@en
P2093
Cristina Oro
David A Jans
Ivan K H Poon
Jingpu Zhang
Manisha M Dias
P304
P356
10.1158/0008-5472.CAN-05-1370
P407
P577
2005-08-01T00:00:00Z