Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models.
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A novel HSF1-mediated death pathway that is suppressed by heat shock proteinsTherapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorderMouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.Therapeutic Approaches for Inhibition of Protein Aggregation in Huntington's DiseaseHeat shock transcription factor 1 as a therapeutic target in neurodegenerative diseasesHDAC4-myogenin axis as an important marker of HD-related skeletal muscle atrophyHsf1 activation inhibits rapamycin resistance and TOR signaling in yeast revealed by combined proteomic and genetic analysisAnalysis of HSF4 binding regions reveals its necessity for gene regulation during development and heat shock response in mouse lensesHDAC6 is a target for protection and regeneration following injury in the nervous systemHSF1 protects neurons through a novel trimerization- and HSP-independent mechanismA novel mouse HSF3 has the potential to activate nonclassical heat-shock genes during heat shockAltered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease.Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteinsModulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative diseaseManipulating heat shock factor-1 in Xenopus tadpoles: neuronal tissues are refractory to exogenous expression.The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice.Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling.Prevention of UVB radiation-induced epidermal damage by expression of heat shock protein 70.Deciphering human heat shock transcription factor 1 regulation via post-translational modification in yeast.Suppression of melanin production by expression of HSP70Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1.HSF1 and HSF3 cooperatively regulate the heat shock response in lizards.Endoplasmic reticulum-associated degradation of Niemann-Pick C1: evidence for the role of heat shock proteins and identification of lysine residues that accept ubiquitin.Proteostasis in striatal cells and selective neurodegeneration in Huntington's disease.Hsp70 and its molecular role in nervous system diseasesHeat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT.Preclinical and clinical investigations of mood stabilizers for Huntington's disease: what have we learned?Skeletal muscle pathology in Huntington's diseaseIndole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models.Electroconvulsive shock ameliorates disease processes and extends survival in huntingtin mutant mice.Identification of HYPK-interacting proteins reveals involvement of HYPK in regulating cell growth, cell cycle, unfolded protein response and cell death.Impaired hippocampal spinogenesis and neurogenesis and altered affective behavior in mice lacking heat shock factor 1.Transcriptional activation of the anchoring protein SAP97 by heat shock factor (HSF)-1 stabilizes K(v) 1.5 channels in HL-1 cells.Heat shock factor 1 over-expression protects against exposure of hydrophobic residues on mutant SOD1 and early mortality in a mouse model of amyotrophic lateral sclerosis.Mitochondrial aldehyde dehydrogenase 2 plays protective roles in heart failure after myocardial infarction via suppression of the cytosolic JNK/p53 pathway in miceLarge-scale RNA interference screening in mammalian cells identifies novel regulators of mutant huntingtin aggregation.Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregation.Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies.Combined treatment with the mood stabilizers lithium and valproate produces multiple beneficial effects in transgenic mouse models of Huntington's disease.HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span
P2860
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P2860
Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Active HSF1 significantly supp ...... in cellular and mouse models.
@en
type
label
Active HSF1 significantly supp ...... in cellular and mouse models.
@en
prefLabel
Active HSF1 significantly supp ...... in cellular and mouse models.
@en
P2093
P2860
P356
P1476
Active HSF1 significantly supp ...... in cellular and mouse models.
@en
P2093
Akira Nakai
Eiichi Takaki
Mitsuaki Fujimoto
Sachiye Inouye
Tetsuya Hayashi
Yasunori Tanaka
Yasushi Kitaura
P2860
P304
34908-34916
P356
10.1074/JBC.M506288200
P407
P577
2005-07-28T00:00:00Z