about
Genetic susceptibility of newborn daughters to oxidative stressCauses of genome instability: the effect of low dose chemical exposures in modern societyMicronuclei in neonates and children: effects of environmental, genetic, demographic and disease variablesAssessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge aheadMolecular mechanisms by which in vivo exposure to exogenous chemical genotoxic agents can lead to micronucleus formation in lymphocytes in vivo and ex vivo in humans.An aphidicolin-block nucleotide excision repair assay measuring DNA incision and repair capacity.The HUMN and HUMNxL international collaboration projects on human micronucleus assays in lymphocytes and buccal cells--past, present and future.STrengthening the Reporting of OBservational studies in Epidemiology: Molecular Epidemiology STROBE-ME. An extension of the STROBE statement.Influence of serum on in situ proliferation and genotoxicity in A549 human lung cells exposed to nanomaterials.STrengthening the Reporting of OBservational studies in Epidemiology--Molecular Epidemiology (STROBE-ME): an extension of the STROBE Statement.Importance of detecting numerical versus structural chromosome aberrations.Indirect mechanisms of genotoxicity.Maternal and gestational factors and micronucleus frequencies in umbilical blood: the NewGeneris Rhea cohort in CreteCobalt and antimony: genotoxicity and carcinogenicity.Human population studies with cytogenetic biomarkers: review of the literature and future prospectives.Mitotic checkpoints and the maintenance of the chromosome karyotype.Survival of aneuploid, micronucleated and/or polyploid cells: crosstalk between ploidy control and apoptosis.The micronucleus assay in human buccal cells as a tool for biomonitoring DNA damage: the HUMN project perspective on current status and knowledge gaps.Exposure to brominated trihalomethanes in water during pregnancy and micronuclei frequency in maternal and cord blood lymphocytes.Micronuclei in cord blood lymphocytes and associations with biomarkers of exposure to carcinogens and hormonally active factors, gene polymorphisms, and gene expression: the NewGeneris cohortPhenotyping for DNA repair capacity.Micronucleus assay and labeling of centromeres with FISH technique.Induction of chromosome malsegregation by nanomaterials.Genetic polymorphisms of genes involved in DNA repair and metabolism influence micronucleus frequencies in human peripheral blood lymphocytes.Automated image analysis of micronuclei by IMSTAR for biomonitoring.In vitro genotoxicity testing using the micronucleus assay in cell lines, human lymphocytes and 3D human skin models.Potential thresholds for genotoxic effects by micronucleus scoring.The in vitro MN assay in 2011: origin and fate, biological significance, protocols, high throughput methodologies and toxicological relevance.Cytogenetic methods in human biomonitoring: principles and uses.HUMN project initiative and review of validation, quality control and prospects for further development of automated micronucleus assays using image cytometry systems.Commentary: critical questions, misconceptions and a road map for improving the use of the lymphocyte cytokinesis-block micronucleus assay for in vivo biomonitoring of human exposure to genotoxic chemicals-a HUMN project perspective.Are genetic polymorphisms in OGG1, XRCC1 and XRCC3 genes predictive for the DNA strand break repair phenotype and genotoxicity in workers exposed to low dose ionising radiations?Cytogenetic effects in children and mothers exposed to air pollution assessed by the frequency of micronuclei and fluorescence in situ hybridization (FISH): a family pilot study in the Czech Republic.Epigenetic memory in response to environmental stressors.Biomonitoring of genotoxic effects for human exposure to nanomaterials: The challenge ahead.Morphological observation of embryoid bodies completes the in vitro evaluation of nanomaterial embryotoxicity in the embryonic stem cell test (EST).Amorphous silica nanoparticles alter microtubule dynamics and cell migration.Towards a New Paradigm in Nano-Genotoxicology: Facing Complexity of Nanomaterials' Cellular Interactions and Effects.Reprint of "Biomonitoring of genotoxic effects for human exposure to nanomaterials: The challenge ahead".The ex vivo L-CBMN assay detects significant human exposure to butadiene.
P50
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P50
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onderzoeker
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Micheline Kirsch-Volders
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Micheline Kirsch-Volders
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Micheline Kirsch-Volders
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Micheline Kirsch-Volders
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Micheline Kirsch-Volders
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Micheline Kirsch-Volders
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Micheline Kirsch-Volders
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Micheline Kirsch-Volders
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Micheline Kirsch-Volders
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Micheline Kirsch-Volders
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Micheline Kirsch-Volders
@sl