Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells.
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Downregulation of Rap1GAP contributes to Ras transformationEpigenetic therapies for chemoresensitization of epithelial ovarian cancer.The Ras effector RASSF2 controls the PAR-4 tumor suppressor.Highly frequent promoter methylation and PIK3CA amplification in non-small cell lung cancer (NSCLC).Suppression of TET1-dependent DNA demethylation is essential for KRAS-mediated transformation.OGDHL is a modifier of AKT-dependent signaling and NF-κB function.RGS6 suppresses Ras-induced cellular transformation by facilitating Tip60-mediated Dnmt1 degradation and promoting apoptosis.Ras and Rac1, frequently mutated in melanomas, are activated by superoxide anion, modulate Dnmt1 level and are causally related to melanocyte malignant transformation.Epigenomics and ovarian carcinoma.The BRAF(V600E) causes widespread alterations in gene methylation in the genome of melanoma cells.Par-4 binds to topoisomerase 1 and attenuates its DNA relaxation activityDNMT1, DNMT3A and DNMT3B gene variants in relation to ovarian cancer risk in the Polish populationRasV12-mediated down-regulation of CCAAT/enhancer binding protein beta in immortalized fibroblasts requires loss of p19Arf and facilitates bypass of oncogene-induced senescenceDNA methylation-mediated nucleosome dynamics and oncogenic Ras signaling: insights from FAS, FAS ligand and RASSF1A.Minireview: epigenetic changes in ovarian cancer.Post-translational regulation of the cleaved fragment of Par-4 in ovarian and endometrial cancer cells.Simultaneous dual targeting of Par-4 and G6PD: a promising new approach in cancer therapy? Quintessence of a literature review on survival requirements of tumor cells.Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation.Par-4 prevents breast cancer recurrencePAR-4 as a possible new target for pancreatic cancer therapy.Cancer-selective apoptotic effects of extracellular and intracellular Par-4.Redefining regulation of DNA methylation by RNA interference.Hypomethylating agents for urologic cancers.Par-4 as a potential target for cancer therapy.A star is born: new insights into the mechanism of astrogenesis.N-hexane inhalation during pregnancy alters DNA promoter methylation in the ovarian granulosa cells of rat offspring.A journey beyond apoptosis: new enigma of controlling metastasis by pro-apoptotic Par-4.Par-4 dependent modulation of cellular β-catenin by medicinal plant natural product derivative 3-azido Withaferin A.PAWR-mediated suppression of BCL2 promotes switching of 3-azido withaferin A (3-AWA)-induced autophagy to apoptosis in prostate cancer cells.Oncogenic nature of a novel mutant AATF and its interactome existing within human cancer cells.TMZ-induced PrPc/par-4 interaction promotes the survival of human glioma cells.Role of BRAF-V600E in the serrated pathway of colorectal tumourigenesis.Oxidative stress modulates DNA methylation during melanocyte anchorage blockade associated with malignant transformation.Epigenetic effects of ethanol on liver and gastrointestinal injury.RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia.Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus.
P2860
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P2860
Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Ras-mediated loss of the pro-a ...... cascades in epithelial cells.
@en
type
label
Ras-mediated loss of the pro-a ...... cascades in epithelial cells.
@en
prefLabel
Ras-mediated loss of the pro-a ...... cascades in epithelial cells.
@en
P2093
P2860
P356
P1476
Ras-mediated loss of the pro-a ...... cascades in epithelial cells.
@en
P2093
Aylin S Ulkü
Channing J Der
Janiel M Shields
Karen Frantz
Kevin Pruitt
Rafael J Rojas
Vanessa M Muniz-Medina
Vivek M Rangnekar
P2860
P304
23363-23370
P356
10.1074/JBC.M503083200
P407
P577
2005-04-14T00:00:00Z