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Structure- and substrate-based inhibitor design for Clostridium botulinum neurotoxin serotype ASubstrate Binding Mode and Its Implication on Drug Design for Botulinum Neurotoxin AStructural Framework for Covalent Inhibition of Clostridium botulinum Neurotoxin A by Targeting Cys165Microbe HuntingSubstrates and controls for the quantitative detection of active botulinum neurotoxin in protease-containing samplesVaccination with recombinant whole heavy chain fragments of Clostridium botulinum Type C and D neurotoxins.Identification of a Natural Product Antagonist against the Botulinum Neurotoxin Light Chain ProteasePurification, potency, and efficacy of the botulinum neurotoxin type A binding domain from Pichia pastoris as a recombinant vaccine candidate.Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease.Characterization of botulinum progenitor toxins by mass spectrometry.Pure botulinum neurotoxin is absorbed from the stomach and small intestine and produces peripheral neuromuscular blockade.A platform stratifying a sequestering agent and a pharmacological antagonist as a means to negate botulinum neurotoxicityHypersensitive detection and quantitation of BoNT/A by IgY antibody against substrate linear-peptideInhalational poisoning by botulinum toxin and inhalation vaccination with its heavy-chain component.Capsaicin protects mouse neuromuscular junctions from the neuroparalytic effects of botulinum neurotoxin aNew perspectives on dystonia.Recovery of a strain of Clostridium botulinum producing both neurotoxin A and neurotoxin B from canned macrobiotic foodSensing the deadliest toxin: technologies for botulinum neurotoxin detection.Progress toward development of an inhalation vaccine against botulinum toxin.Synthesis and structure-activity relationships of second-generation hydroxamate botulinum neurotoxin A protease inhibitors.Use of Monoclonal Antibodies in the Sensitive Detection and Neutralization of Botulinum Neurotoxin Serotype B.The C-terminus of Botulinum A Protease Has Profound and Unanticipated Kinetic Consequences Upon the Catalytic Cleft.The strange case of the botulinum neurotoxin: using chemistry and biology to modulate the most deadly poison.Refractory overactive bladder: Beyond oral anticholinergic therapyGenetic characterization of Clostridium botulinum associated with type B infant botulism in Japan.Antibody protection against botulinum neurotoxin intoxication in mice.4-Amino-7-chloroquinolines: probing ligand efficiency provides botulinum neurotoxin serotype A light chain inhibitors with significant antiprotozoal activityTargeting botulinum A cellular toxicity: a prodrug approach.Molecular characterization of Clostridium botulinum isolates from foodborne outbreaks in Thailand, 2010.Molecular structures and functional relationships in clostridial neurotoxins.Analysis of neurotoxin cluster genes in Clostridium botulinum strains producing botulinum neurotoxin serotype A subtypes.Characterization of the hemorrhagic reaction caused by Vibrio vulnificus metalloprotease, a member of the thermolysin family.Investigating novel therapeutic targets and molecular mechanisms to treat botulinum neurotoxin A intoxication.Characterization of SNARE cleavage products generated by formulated botulinum neurotoxin type-a drug products.Structure and enzymatic activity of botulinum neurotoxins.Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication.Toward the discovery of potent inhibitors of botulinum neurotoxin A: development of a robust LC MS based assay operational from low to subnanomolar enzyme concentrations.Identification and characterization of functional subunits of Clostridium botulinum type A progenitor toxin involved in binding to intestinal microvilli and erythrocytes.Building-block architecture of botulinum toxin complex: Conformational changes provide insights into the hemagglutination ability of the complex.Binding and transcytosis of botulinum neurotoxin by polarized human colon carcinoma cells.
P2860
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P2860
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Structure and function of Clostridium botulinum toxins.
@en
type
label
Structure and function of Clostridium botulinum toxins.
@en
prefLabel
Structure and function of Clostridium botulinum toxins.
@en
P2093
P2860
P1476
Structure and function of Clostridium botulinum toxins.
@en
P2093
P2860
P304
P356
10.1111/J.1348-0421.1995.TB02184.X
P577
1995-01-01T00:00:00Z