about
Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complexDevelopment of renal-targeted vectors through combined in vivo phage display and capsid engineering of adenoviral fibers from serotype 19p.Inhibition of intravascular thrombosis in murine endotoxemia by targeted expression of hirudin and tissue factor pathway inhibitor analogs to activated endothelium.Enhanced effect of inhibition of thrombin on endothelium in murine endotoxaemia: specific inhibition of thrombocytopenia.Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectorsYour bleeding heart: lessons from low tissue factor expression in mice.450 million years of hemostasis.Manipulating adenovirus hexon hypervariable loops dictates immune neutralisation and coagulation factor X-dependent cell interaction in vitro and in vivoAAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage.Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variantThe influence of blood on in vivo adenovirus bio-distribution and transduction.Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer.Temporal expression of alternatively spliced forms of tissue factor pathway inhibitor in mice.The regulated long-term delivery of therapeutic proteins by using antigen-specific B lymphocytes.Adenovirus 5 fibers mutated at the putative HSPG-binding site show restricted retargeting with targeting peptides in the HI loop.The role of the tissue factor pathway in haemostasis and beyond.Influence of coagulation factor x on in vitro and in vivo gene delivery by adenovirus (Ad) 5, Ad35, and chimeric Ad5/Ad35 vectorsEffect of neutralizing sera on factor x-mediated adenovirus serotype 5 gene transfer.Engineering adeno-associated virus 2 vectors for targeted gene delivery to atherosclerotic lesions.Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes.A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome.Tissue factor pathway.Hyperactive piggyBac transposons for sustained and robust liver-targeted gene therapy.Expression of human tissue factor pathway inhibitor on vascular smooth muscle cells inhibits secretion of macrophage migration inhibitory factor and attenuates atherosclerosis in ApoE-/- mice.Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1-dependent leukocyte recruitment in vivo.Influence of coagulation factor zymogens on the infectivity of adenoviruses pseudotyped with fibers from subgroup D.Targeting of adenovirus serotype 5 (Ad5) and 5/47 pseudotyped vectors in vivo: fundamental involvement of coagulation factors and redundancy of CAR binding by Ad5.Interferon-gamma modulates prolactin and tissue factor expression in differentiating human endometrial stromal cells.An in-frame insertion in the prion protein gene in familial Creutzfeldt-Jakob disease.Characterization of a recent retroposon insertion on mouse chromosome 2 and localization of the cognate parental gene to chromosome 11.Mouse adenovirus type 1 and human adenovirus type 5 differ in endothelial cell tropism and liver targeting.Expression of tissue factor and initiation of clotting by human platelets and monocytes after incubation with porcine endothelial cells.In utero administration of Ad5 and AAV pseudotypes to the fetal brain leads to efficient, widespread and long-term gene expression.Detection and characterisation of two missense mutations at a cleavage site in the factor VIII light chain.Two novel mutations in severe factor VII deficiency.Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium.Regulated inhibition of coagulation by porcine endothelial cells expressing P-selectin-tagged hirudin and tissue factor pathway inhibitor fusion proteins.Analysis of the consequences of premature termination codons within factor VIII coding sequences.Codon optimization of human factor VIII cDNAs leads to high-level expression.Adenovirus serotype 5 hexon mediates liver gene transfer.
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hulumtues
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հետազոտող
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John H. McVey
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John H. McVey
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John H. McVey
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John H. McVey
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John H. McVey
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John H. McVey
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John H. McVey
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John H. McVey
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John H. McVey
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John H. McVey
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John H. McVey
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John H. McVey
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John H. McVey
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John H. McVey
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John H. McVey
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P106
P1153
7005492040
P21
P31
P496
0000-0002-7416-533X