Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth. - Wikidata - wikimedia - TriplyDB

Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth.

Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth.

http://www.wikidata.org/entity/Q40443893

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Combined RNAi-mediated suppression of Rictor and EGFR resulted in complete tumor regression in an orthotopic glioblastoma tumor model Loss of PTEN is not associated with poor survival in newly diagnosed glioblastoma patients of the temozolomide era.Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3β (GSK-3beta) phosphorylation USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses Anti-angiogenic therapy induces integrin-linked kinase 1 up-regulation in a mouse model of glioblastoma In vitro antitumor activity of stellettin B, a triterpene from marine sponge Jaspis stellifera, on human glioblastoma cancer SF295 cells.Androgen receptor promotes gastric cancer cell migration and invasion via AKT-phosphorylation dependent upregulation of matrix metalloproteinase 9 Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell Lines.Activation of casein kinase II and inhibition of phosphatase and tensin homologue deleted on chromosome 10 phosphatase by nerve growth factor/p75NTR inhibit glycogen synthase kinase-3beta and stimulate axonal growth Integrin-linked kinase controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligase Integrin-linked kinase as a target for ERG-mediated invasive properties in prostate cancer models Malignant gliomas: strategies to increase the effectiveness of targeted molecular treatment.Using Pharmacokinetic Profiles and Digital Quantification of Stained Tissue Microarrays as a Medium-Throughput, Quantitative Method for Measuring the Kinetics of Early Signaling Changes Following Integrin-Linked Kinase Inhibition in an In Vivo Model The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer.Inhibiting kinases in malignant gliomas.Particularly interesting cysteine- and histidine-rich protein in cardiac development and remodeling.PI3 kinase/AKT pathway as a therapeutic target in multiple myeloma.Contributions of integrin-linked kinase to breast cancer metastasis and tumourigenesis.QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatmen Type II cGMP-dependent protein kinase inhibits epidermal growth factor-induced phosphatidylinositol-3-kinase/Akt signal transduction in gastric cancer cells.Critical role of integrin-linked kinase in granule cell precursor proliferation and cerebellar development.There's something about ILK.Novel anti-cancer compounds for developing combinatorial therapies to target anoikis-resistant tumors.Role of Akt in human malignant glioma: from oncogenesis to tumor aggressiveness.Integrin-linked kinase in gastric cancer cell attachment, invasion and tumor growth.Releasing 'brakes' to nerve regeneration: intrinsic molecular targets.ILK and cytoskeletal architecture: an important determinant of AQP2 recycling and subsequent entry into the exocytotic pathway.A novel role of ribonuclease inhibitor in regulation of epithelial-to-mesenchymal transition and ILK signaling pathway in bladder cancer cells.HDAC inhibitor DWP0016 activates p53 transcription and acetylation to inhibit cell growth in U251 glioblastoma cells.Deltonin, a steroidal saponin, inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis and antiangiogenesis.HIPPO-Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension.Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells.Ginkgol C17:1 inhibits tumor growth by blunting the EGF- PI3K/Akt signaling pathway.Inhibition of Necl-5 (CD155/PVR) reduces glioblastoma dispersal and decreases MMP-2 expression and activity.Integrin-linked kinase (ILK) expression correlates with tumor severity in clear cell renal carcinoma.Balance between apoptosis or survival induced by changes in extracellular-matrix composition in human mesangial cells: a key role for ILK-NFκB pathway.Effect of uraemia on endothelial cell damage is mediated by the integrin linked kinase pathway.Nanoparticle-Loaded Protein-Polymer Nanodroplets for Improved Stability and Conversion Efficiency in Ultrasound Imaging and Drug Delivery.Periostin Enhances Migration, Invasion, and Adhesion of Human Endometrial Stromal Cells Through Integrin-Linked Kinase 1/Akt Signaling Pathway.

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Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth.

http://www.wikidata.org/entity/Q40443893

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2005 nî lūn-bûn

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Inhibition of ILK in PTEN-muta ...... osis, and delays tumor growth.

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type

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Inhibition of ILK in PTEN-muta ...... osis, and delays tumor growth.

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Inhibition of ILK in PTEN-muta ...... osis, and delays tumor growth.

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Inhibition of ILK in PTEN-muta ...... tosis, and delays tumor growth

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B Thiessen

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Lincoln A Edwards

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Marcel B Bally

http://www.w3.org/2001/XMLSchema#string

Tim Daynard

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Wieslawa H Dragowska

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P2860

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways

The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways.

Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor

Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

The role of MMAC1 mutations in early-onset breast cancer: causative in association with Cowden syndrome and excluded in BRCA1-negative cases.

Pharmacodynamic behavior of liposomal antisense oligonucleotides targeting Her-2/neu and vascular endothelial growth factor in an ascitic MDA435/LCC6 human breast cancer model.

Integrin-linked kinase regulates inducible nitric oxide synthase and cyclooxygenase-2 expression in an NF-kappa B-dependent manner.

Inactivation of integrin-linked kinase induces aberrant tau phosphorylation via sustained activation of glycogen synthase kinase 3beta in N1E-115 neuroblastoma cells.

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