The C-terminal sterile alpha motif and the extreme C terminus regulate the transcriptional activity of the alpha isoform of p73.
about
Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathwayDEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence.DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiationThe p73 tumor suppressor is targeted by Pirh2 RING finger E3 ubiquitin ligase for the proteasome-dependent degradation.Induction of apoptotic genes by a p73-phosphatase and tensin homolog (p73-PTEN) protein complex in response to genotoxic stress.p53, a target of estrogen receptor (ER) α, modulates DNA damage-induced growth suppression in ER-positive breast cancer cells.The functional domains in p53 family proteins exhibit both common and distinct properties.Tissue-specific expression of p73 C-terminal isoforms in mice.P73 and age-related diseases: is there any link with Parkinson Disease?TAp73beta and DNp73beta activate the expression of the pro-survival caspase-2Sp73alpha isoforms drive opposite transcriptional and post-transcriptional regulation of MYCN expression in neuroblastoma cellsID1, inhibitor of differentiation/DNA binding, is an effector of the p53-dependent DNA damage response pathway.RNA-binding Protein PCBP2 Regulates p73 Expression and p73-dependent Antioxidant DefenseCataloging and organizing p73 interactions in cell cycle arrest and apoptosisTherapeutic prospects for p73 and p63: rising from the shadow of p53.Functions, divergence and clinical value of TAp73 isoforms in cancer.p53- and p73-independent activation of TIGAR expression in vivo.DEC1 coordinates with HDAC8 to differentially regulate TAp73 and ΔNp73 expression.The BAG-1 cochaperone is a negative regulator of p73-dependent transcription.PPM1D430, a novel alternative splicing variant of the human PPM1D, can dephosphorylate p53 and exhibits specific tissue expression.p73 expression modulates p63 and Mdm2 protein presence in complex with p53 family-specific DNA target sequence in squamous cell carcinogenesis.Gene expression of cyclin-dependent kinase subunit Cks2 is repressed by the tumor suppressor p53 but not by the related proteins p63 or p73.Transcriptional regulation by p53 and p73.Family members p53 and p73 act together in chromatin modification and direct repression of alpha-fetoprotein transcription.∆Np73 is capable of inducing apoptosis by co-ordinately activating several BH3-only proteins.Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism.p73 Alternative Splicing: Exploring a Biological Role for the C-Terminal Isoforms.p19rasAccelerates p73β‐mediated apoptosis through a caspase‐3 dependent pathwayMelanoma cells resistant towards MAPK inhibitors exhibit reduced TAp73 expression mediating enhanced sensitivity to platinum-based drugs
P2860
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P2860
The C-terminal sterile alpha motif and the extreme C terminus regulate the transcriptional activity of the alpha isoform of p73.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
The C-terminal sterile alpha m ...... y of the alpha isoform of p73.
@en
type
label
The C-terminal sterile alpha m ...... y of the alpha isoform of p73.
@en
prefLabel
The C-terminal sterile alpha m ...... y of the alpha isoform of p73.
@en
P2860
P356
P1476
The C-terminal sterile alpha m ...... ty of the alpha isoform of p73
@en
P2093
Xinbin Chen
P2860
P304
20111-20119
P356
10.1074/JBC.M413889200
P407
P50
P577
2005-03-15T00:00:00Z