Proteasome inhibition alters glucose-stimulated (pro)insulin secretion and turnover in pancreatic {beta}-cells.
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Excessive islet NO generation in type 2 diabetic GK rats coincides with abnormal hormone secretion and is counteracted by GLP-1.Gene expression profiles in Atlantic salmon adipose-derived stromo-vascular fraction during differentiation into adipocytes.Misfolded proinsulin affects bystander proinsulin in neonatal diabetesDegradation of an intramitochondrial protein by the cytosolic proteasomeThe regulation and turnover of mitochondrial uncoupling proteins.PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway.Substrate-favored lysosomal and proteasomal pathways participate in the normal balance control of insulin precursor maturation and disposal in β-cells.Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion.Withaferin A induces proteasome inhibition, endoplasmic reticulum stress, the heat shock response and acquisition of thermotolerance.Proteasome dysfunction mediates high glucose-induced apoptosis in rodent beta cells and human isletsRetinal proteins associated with redox regulation and protein folding play central roles in response to high glucose conditions.Investigational agents that protect pancreatic islet beta-cells from failure.Opposite effects of proteasome inhibitors in the adrenergic induction of arylalkylamine N-acetyltransferase in rat pinealocytes.Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets.Emerging roles for the ubiquitin-proteasome system and autophagy in pancreatic beta-cells.Genetics of type 2 diabetes in East Asian populations.Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart.High glucose-induced proteome alterations in retinal pigmented epithelium cells and its possible relevance to diabetic retinopathy.Putative association between UBE2E2 polymorphisms and the risk of gestational diabetes mellitus.Activation of PERK kinase in neural cells by proteasome inhibitor treatment.Protective role for nitric oxide during the endoplasmic reticulum stress response in pancreatic beta-cells.Genetic variations in the PSMA3, PSMA6 and PSMC6 genes are associated with type 1 diabetes in Latvians and with expression level of number of UPS-related and T1DM-susceptible genes in HapMap individuals.Endoplasmic reticulum stress and the unfolded protein response regulate genomic cystic fibrosis transmembrane conductance regulator expression.Essential role of ubiquitin-proteasome system in normal regulation of insulin secretion.Proteasome inhibitors, including curcumin, improve pancreatic β-cell function and insulin sensitivity in diabetic mice.Proteins in the insulin-secreting cell line MIN6 bind the imidazoline compound BL11282.The ubiquitin-proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic β-cells.Intracellular degradation of insulin and crinophagy are maintained by nitric oxide and cyclo-oxygenase 2 activity in isolated pancreatic islets.The immunoproteasome is induced by cytokines and regulates apoptosis in human islets.A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B
P2860
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P2860
Proteasome inhibition alters glucose-stimulated (pro)insulin secretion and turnover in pancreatic {beta}-cells.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Proteasome inhibition alters g ...... er in pancreatic {beta}-cells.
@en
type
label
Proteasome inhibition alters g ...... er in pancreatic {beta}-cells.
@en
prefLabel
Proteasome inhibition alters g ...... er in pancreatic {beta}-cells.
@en
P2093
P2860
P356
P1476
Proteasome inhibition alters g ...... ver in pancreatic {beta}-cells
@en
P2093
Clayton E Mathews
Edward H Leiter
Kajorn Kitiphongspattana
P2860
P304
15727-15734
P356
10.1074/JBC.M410876200
P407
P50
P577
2005-02-09T00:00:00Z