Identification of differentially activated cell-signaling networks associated with pichinde virus pathogenesis by using systems kinomics.
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Inhibition of Innate Immune Responses Is Key to Pathogenesis by ArenavirusesProteomic analysis of Pichindé virus infection identifies differential expression of prothymosin-alpha.Attenuated and lethal variants of Pichindé virus induce differential patterns of NF-kappaB activation suggesting a potential target for novel therapeutics.Comparative pathogenesis and systems biology for biodefense virus vaccine development.Systems kinomics demonstrates Congo Basin monkeypox virus infection selectively modulates host cell signaling responses as compared to West African monkeypox virus.Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysisA systems biology starter kit for arenaviruses.Characterization of the host response to pichinde virus infection in the Syrian golden hamster by species-specific kinome analysisGenomic profiling of host responses to Lassa virus: therapeutic potential from primate to manExploring kinase inhibitors as therapies for human arenavirus infections.Expression of interferon-induced antiviral genes is delayed in a STAT1 knockout mouse model of Crimean-Congo hemorrhagic fever.An attenuated Lassa vaccine in SIV-infected rhesus macaques does not persist or cause arenavirus disease but does elicit Lassa virus-specific immunity.Analysis of the differential host cell nuclear proteome induced by attenuated and virulent hemorrhagic arenavirus infectionInnate immune response to arenaviral infection: a focus on the highly pathogenic New World hemorrhagic arenaviruses.Deciphering enzyme function using peptide arrays.Vaccine and adjuvant design for emerging viruses: mutations, deletions, segments and signaling.Host cell factors as antiviral targets in arenavirus infection.Kinome profiling.Systems kinomics for characterizing host responses to high-consequence pathogens at the NIH/NIAID Integrated Research Facility-Frederick.Viruses exploit the function of epidermal growth factor receptor.Meta-analysis of high-throughput datasets reveals cellular responses following hemorrhagic fever virus infection.Inhibition of Lassa virus and Ebola virus infection in host cells treated with the kinase inhibitors genistein and tyrphostin.Genistein treatment of cells inhibits arenavirus infection.In silico pathway analysis: the final frontier towards completely rational drug design.Early blood profiles of virus infection in a monkey model for Lassa fever.Arenavirus nucleoproteins prevent activation of nuclear factor kappa B.Gene expression in primate liver during viral hemorrhagic fever.Genome comparison of virulent and avirulent strains of the Pichinde arenavirus.Methamphetamine mediates immune dysregulation in a murine model of chronic viral infection.Porcine epidemic diarrhea virus-induced epidermal growth factor receptor activation impairs the antiviral activity of type I interferon.Methods and approaches to disease mechanisms using systems kinomics.
P2860
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P2860
Identification of differentially activated cell-signaling networks associated with pichinde virus pathogenesis by using systems kinomics.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Identification of differential ...... sis by using systems kinomics.
@en
type
label
Identification of differential ...... sis by using systems kinomics.
@en
prefLabel
Identification of differential ...... sis by using systems kinomics.
@en
P2093
P2860
P356
P1433
P1476
Identification of differential ...... sis by using systems kinomics.
@en
P2093
Barry L Elsom
Bruce A Luxon
David G Gorenstein
Erin P Scott
Gavin C Bowick
Heidi M Spratt
Judith F Aronson
Lihong Zhang
Norbert K Herzog
Susan M Fennewald
P2860
P304
P356
10.1128/JVI.02199-06
P407
P577
2006-12-06T00:00:00Z