A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation. - Wikidata - wikimedia - TriplyDB

A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation.

A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation.

http://www.wikidata.org/entity/Q40464017

about

Raf family kinases: old dogs have learned new tricks Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin The role of small adaptor proteins in the control of oncogenic signalingr driven by tyrosine kinases in human cancer Emerging roles for intersectin (ITSN) in regulating signaling and disease pathways Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases Steering tumor progression through the transcriptional response to growth factors and stroma Integrated genomic characterization reveals novel, therapeutically relevant drug targets in FGFR and EGFR pathways in sporadic intrahepatic cholangiocarcinoma Gene 33/Mig6 inhibits hexavalent chromium-induced DNA damage and cell transformation in human lung epithelial cells Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation Glucocorticoid-induced suppression of β-cell proliferation is mediated by Mig6 ERbeta1 represses basal breast cancer epithelial to mesenchymal transition by destabilizing EGFR Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor.Mig6 haploinsufficiency protects mice against streptozotocin-induced diabetes Cancer-type regulation of MIG-6 expression by inhibitors of methylation and histone deacetylation.Decreased Mitogen Inducible Gene 6 (MIG-6) Associated with Symptom Severity in Children with Autism.Mig-6 overcomes gefitinib resistance by inhibiting EGFR/ERK pathway in non-small cell lung cancer cell lines.Pathways driving the endocytosis of mutant and wild-type EGFR in cancer.The relative expression of Mig6 and EGFR is associated with resistance to EGFR kinase inhibitors.Whole genome sequencing of glioblastoma multiforme identifies multiple structural variations involved in EGFR activation PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression.Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma.Thyroid-specific knockout of the tumor suppressor mitogen-inducible gene 6 activates epidermal growth factor receptor signaling pathways and suppresses nuclear factor-κB activity Mitogen-inducible gene 6 triggers apoptosis and exacerbates ER stress-induced β-cell death.MIG6 Is MEK Regulated and Affects EGF-Induced Migration in Mutant NRAS Melanoma.Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6 Endocytosis of receptor tyrosine kinases Mig6 is a sensor of EGF receptor inactivation that directly activates c-Abl to induce apoptosis during epithelial homeostasis Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation.A module of inflammatory cytokines defines resistance of colorectal cancer to EGFR inhibitors.Disturbed cartilage and joint homeostasis resulting from a loss of mitogen-inducible gene 6 in a mouse model of joint dysfunction.Type I γ Phosphatidylinositol Phosphate 5-Kinase i5 Controls the Ubiquitination and Degradation of the Tumor Suppressor Mitogen-inducible Gene 6 Intersectin scaffold proteins and their role in cell signaling and endocytosis.Differential parsing of EGFR endocytic flux among parallel internalization pathways in lung cancer cells with EGFR-activating mutations.ErbB2 dephosphorylation and anti-proliferative effects of neuregulin-1 in ErbB2-overexpressing cells; re-evaluation of their low-affinity interaction.Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling.Downregulation of Mig-6 in nonsmall-cell lung cancer is associated with EGFR signaling.Biology using engineering tools: the negative feedback amplifier.A pervasive role for MIG6 in restraining cell proliferation.Endocytosis and cancer.

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P2860

A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation.

http://www.wikidata.org/entity/Q40464017

description

2010 nî lūn-bûn

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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2010年论文

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2010年论文

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name

A two-tiered mechanism of EGFR ...... sion and receptor degradation.

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type

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A two-tiered mechanism of EGFR ...... sion and receptor degradation.

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prefLabel

A two-tiered mechanism of EGFR ...... sion and receptor degradation.

@en

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A two-tiered mechanism of EGFR ...... sion and receptor degradation.

@en

P2093

Costanza Ballarò

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Elena Maspero

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Giulia Varsano

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Oreste Segatto

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Sergio Anastasi

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Simona Polo

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Yuri Frosi

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P2860

Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly

The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15.

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

Intersectin regulates epidermal growth factor receptor endocytosis, ubiquitylation, and signaling

Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface

The evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activity

Role of mammalian vacuolar protein-sorting proteins in endocytic trafficking of a non-ubiquitinated G protein-coupled receptor to lysosomes

Intersectin 1 forms a complex with adaptor protein Ruk/CIN85 in vivo independently of epidermal growth factor stimulation

Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation

Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype.

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557-571

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10.1083/JCB.201002032

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3

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189

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Loriana Castellani

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2010-04-26T00:00:00Z

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43345634

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20421427

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2867293

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