Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo. - Wikidata - wikimedia - TriplyDB

Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo.

Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo.

http://www.wikidata.org/entity/Q40472142

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The role of sialomucin CD164 (MGC-24v or endolyn) in prostate cancer metastasis What does the concept of the stem cell niche really mean today?CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression Role of stromal cell-derived factor 1α pathway in bone metastatic prostate cancer Prostate cancer metastasis: roles of recruitment and reprogramming, cell signal network and three-dimensional growth characteristics Therapeutic strategies targeting cancer stem cells The association of CXCR4 expression with clinicopathological significance and potential drug target in prostate cancer: a meta-analysis and literature review A meta-analysis for C-X-C chemokine receptor type 4 as a prognostic marker and potential drug target in hepatocellular carcinoma Targeting bone physiology for the treatment of metastatic prostate cancer CXCR4/CXCL12 in non-small-cell lung cancer metastasis to the brain Growth Arrest-Specific 6 (GAS6) Promotes Prostate Cancer Survival by G1 Arrest/S Phase Delay and Inhibition of Apoptosis During Chemotherapy in Bone Marrow Molecular Mechanisms of Bone Metastasis: Which Targets Came from the Bench to the Bedside?Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells Molecular mechanisms and treatment of bone metastasis.Elucidating a key component of cancer metastasis: CXCL12 (SDF-1α) binding to CXCR4.Interaction between CXCR4 and CCL20 pathways regulates tumor growth.Chemokine receptor CXCR4 expression in hepatocellular carcinoma patients increases the risk of bone metastases and poor survival.Characterization of phosphoglycerate kinase-1 expression of stromal cells derived from tumor microenvironment in prostate cancer progression.Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formation Reversal of chemotherapy-induced leukopenia using granulocyte macrophage colony-stimulating factor promotes bone metastasis that can be blocked with osteoclast inhibitors A novel method for monitoring tumor proliferation in vivo using fluorescent dye DiD Inhibition of metastasis in a castration resistant prostate cancer model by the quinoline-3-carboxamide tasquinimod (ABR-215050).Stromal cell-derived factor 1 regulates the actin organization of chondrocytes and chondrocyte hypertrophy New advances on critical implications of tumor- and metastasis-initiating cells in cancer progression, treatment resistance and disease recurrence Integrins and bone metastasis: integrating tumor cell and stromal cell interactions.SDF-1 promotes endochondral bone repair during fracture healing at the traumatic brain injury condition p21CIP-1/WAF-1 induction is required to inhibit prostate cancer growth elicited by deficient expression of the Wnt inhibitor Dickkopf-1.The host microenvironment influences prostate cancer invasion, systemic spread, bone colonization, and osteoblastic metastasis.Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow Pre-clinical mouse models of human prostate cancer and their utility in drug discovery CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies?WISP1/CCN4: a potential target for inhibiting prostate cancer growth and spread to bone.Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation Annexin 2-CXCL12 interactions regulate metastatic cell targeting and growth in the bone marrow Chemokine receptors in advanced breast cancer: differential expression in metastatic disease sites with diagnostic and therapeutic implications The intricate role of CXCR4 in cancer.Olfactomedin 4 suppresses prostate cancer cell growth and metastasis via negative interaction with cathepsin D and SDF-1.Conditional inactivation of the CXCR4 receptor in osteoprecursors reduces postnatal bone formation due to impaired osteoblast development.Frequent gene products and molecular pathways altered in prostate cancer- and metastasis-initiating cells and their progenies and novel promising multitargeted therapies.CXCR4 is a novel target of cancer chemopreventative isothiocyanates in prostate cancer cells

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P2860

Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo.

http://www.wikidata.org/entity/Q40472142

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Abraham Schneider

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Amy J Koh-Paige

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Evan T Keller

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Hyusuk Shim

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Jianhua Wang

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Jingcheng Wang

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Jinlu Dai

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Kevin Cook

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Laurie K McCauley

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Nadir I Osman

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Rapid and quantitative assessment of cancer treatment response using in vivo bioluminescence imaging

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