Depletion of primary cilia in articular chondrocytes results in reduced Gli3 repressor to activator ratio, increased Hedgehog signaling, and symptoms of early osteoarthritis.
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Cilia/Ift protein and motor -related bone diseases and mouse modelsThe intraflagellar transport protein IFT80 is required for cilia formation and osteogenesisIFT80 is essential for chondrocyte differentiation by regulating Hedgehog and Wnt signaling pathwaysSP8 regulates signaling centers during craniofacial development.Orphan G-protein coupled receptor 22 (Gpr22) regulates cilia length and structure in the zebrafish Kupffer's vesicleThe mechanobiology of articular cartilage: bearing the burden of osteoarthritis.A role for hedgehog signaling in the differentiation of the insertion site of the patellar tendon in the mouse.Function and regulation of primary cilia and intraflagellar transport proteins in the skeletonDeletion of IFT80 Impairs Epiphyseal and Articular Cartilage Formation Due to Disruption of Chondrocyte Differentiation.Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Pathway Is Induced by Mechanical Load and Reduces the Activity of Hedgehog Signaling in Chondrogenic Micromass Cell Cultures.Molecular pathways: the hedgehog signaling pathway in cancer.Unique spatiotemporal requirements for intraflagellar transport genes during forebrain development.Mechanobiology of TGFβ signaling in the skeleton.TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading.Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis.The extracellular matrix and ciliary signalingThe role of hedgehog signalling in skeletal health and disease.IFT88 influences chondrocyte actin organization and biomechanics.Osteoarthritis year in review 2015: mechanics.Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes.Primary Cilia and Intraflagellar Transport Proteins in Bone and Cartilage.Effects of mechanical loading on human mesenchymal stem cells for cartilage tissue engineering.TGF-β Suppresses Ift88 Expression in Chondrocytic ATDC5 Cells.Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium.Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes.Depletion of chondrocyte primary cilia reduces the compressive modulus of articular cartilage.Ift88 regulates Hedgehog signaling, Sfrp5 expression, and β-catenin activity in post-natal growth plateA discoidin domain receptor 1 knock-out mouse as a novel model for osteoarthritis of the temporomandibular joint.The primary cilium as a signaling nexus for growth plate function and subsequent skeletal development.Basic fibroblast growth factor increases IFT88 expression in chondrocytes.WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome.
P2860
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P2860
Depletion of primary cilia in articular chondrocytes results in reduced Gli3 repressor to activator ratio, increased Hedgehog signaling, and symptoms of early osteoarthritis.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Depletion of primary cilia in ...... ptoms of early osteoarthritis.
@en
type
label
Depletion of primary cilia in ...... ptoms of early osteoarthritis.
@en
prefLabel
Depletion of primary cilia in ...... ptoms of early osteoarthritis.
@en
P2093
P2860
P1476
Depletion of primary cilia in ...... ptoms of early osteoarthritis.
@en
P2093
P2860
P304
P356
10.1016/J.JOCA.2011.11.009
P577
2011-11-27T00:00:00Z