Hsp90 is essential for restoring cellular functions of temperature-sensitive p53 mutant protein but not for stabilization and activation of wild-type p53: implications for cancer therapy.
about
High-content, high-throughput analysis of cell cycle perturbations induced by the HSP90 inhibitor XL888Tumor-suppressive maspin regulates cell response to oxidative stress by direct interaction with glutathione S-transferase.BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function.Current strategies for the treatment of Alzheimer's disease and other tauopathies.Synergism of heat shock protein 90 and histone deacetylase inhibitors in synovial sarcoma.Liposomal encapsulation of deguelin: evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis.Mutant p53 accumulation in human breast cancer is not an intrinsic property or dependent on structural or functional disruption but is regulated by exogenous stress and receptor status.IPH-926 lobular breast cancer cells harbor a p53 mutant with temperature-sensitive functional activity and allow for profiling of p53-responsive genes.Switching p53-dependent growth arrest to apoptosis via the inhibition of DNA damage-activated kinases.Regulation of P53 stability in p53 mutated human and mouse hepatoma cells.Folding and misfolding mechanisms of the p53 DNA binding domain at physiological temperature.ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1.Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression.Bipartite Role of Heat Shock Protein 90 (Hsp90) Keeps CRAF Kinase Poised for Activation.DNA modification with cisplatin affects sequence-specific DNA binding of p53 and p73 proteins in a target site-dependent manner.Deregulation of microRNA‑31a‑5p is involved in the development of primary hypertension by suppressing apoptosis of pulmonary artery smooth muscle cells via targeting TP53.
P2860
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P2860
Hsp90 is essential for restoring cellular functions of temperature-sensitive p53 mutant protein but not for stabilization and activation of wild-type p53: implications for cancer therapy.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Hsp90 is essential for restori ...... plications for cancer therapy.
@en
type
label
Hsp90 is essential for restori ...... plications for cancer therapy.
@en
prefLabel
Hsp90 is essential for restori ...... plications for cancer therapy.
@en
P2860
P356
P1476
Hsp90 is essential for restori ...... mplications for cancer therapy
@en
P2093
Borek Vojtesek
Pavla Ceskova
P2860
P304
P356
10.1074/JBC.M412767200
P407
P50
P577
2004-12-21T00:00:00Z