A single amino acid substitution in the central portion of the West Nile virus NS4B protein confers a highly attenuated phenotype in mice.
about
Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemicPredicting Zika virus structural biology: Challenges and opportunities for interventionFlaviviral NS4b, chameleon and jack-in-the-box roles in viral replication and pathogenesis, and a molecular target for antiviral interventionTemperature-sensitive mutations for live-attenuated Rift Valley fever vaccines: implications from other RNA virusesVaccines in development against West Nile virusMechanism of West Nile virus neuroinvasion: a critical appraisalA Novel Synthetic TLR-4 Agonist Adjuvant Increases the Protective Response to a Clinical-Stage West Nile Virus Vaccine Antigen in Multiple FormulationsA Combination of Naturally Occurring Mutations in North American West Nile Virus Nonstructural Protein Genes and in the 3' Untranslated Region Alters Virus PhenotypeThe West Nile virus mutant spectrum is host-dependant and a determinant of mortality in miceWest Nile Virus-Induced Neuroinflammation: Glial Infection and Capsid Protein-Mediated NeurovirulenceDifferential Effects of Mutations in NS4B on West Nile Virus Replication and Inhibition of Interferon SignalingCharacterization of a small plaque variant of West Nile virus isolated in New York in 2000Rapid fixation of a distinctive sequence motif in the 3′ noncoding region of the clade of West Nile virus invading North AmericaIdentification of genetic determinants of a tick-borne flavivirus associated with host-specific adaptation and pathogenicityGenetic Determinants of Virulence in Pathogenic Lineage 2 West Nile Virus StrainsMutations in Classical Swine Fever Virus NS4B Affect Virulence in SwineGlycosylation of the West Nile Virus Envelope Protein Increases In Vivo and In Vitro Viral Multiplication in BirdsA single amino acid substitution in the core protein of West Nile virus increases resistance to acidotropic compoundsInduction of endoplasmic reticulum-derived replication-competent membrane structures by West Nile virus non-structural protein 4BWest Nile virus and its emergence in the United States of America.Structural gene (prME) chimeras of St Louis encephalitis virus and West Nile virus exhibit altered in vitro cytopathic and growth phenotypes.IS-98-ST1 West Nile virus derived from an infectious cDNA clone retains neuroinvasiveness and neurovirulence properties of the original virusFlavivirus-mosquito interactions.Current trends in West Nile virus vaccine development.Virulence determinants between New York 99 and Kunjin strains of West Nile virusImmune responses to an attenuated West Nile virus NS4B-P38G mutant strain.Comparison of the neuropathology induced by two West Nile virus strains.Nonconsensus West Nile virus genomes arising during mosquito infection suppress pathogenesis and modulate virus fitness in vivoWest Nile virus population genetics and evolution.Genetic characterization of West Nile virus lineage 2, Greece, 2010.Mutational analysis of the West Nile virus NS4B protein.Simplifying complex sequence information: a PCP-consensus protein binds antibodies against all four Dengue serotypes.Evaluation of the pathogenicity of West Nile virus (WNV) lineage 2 strains in a SPF chicken model of infection: NS3-249Pro mutation is neither sufficient nor necessary for conferring virulence.In Vitro and in Vivo Evaluation of Mutations in the NS Region of Lineage 2 West Nile Virus Associated with Neuroinvasiveness in a Mammalian Model.Immunodominant West Nile Virus T Cell Epitopes Are Fewer in Number and Fashionably Late.Increased early RNA replication by chimeric West Nile virus W956IC leads to IPS-1-mediated activation of NF-κB and insufficient virus-mediated counteraction of the resulting canonical type I interferon signalingWest Nile virus NS2A protein facilitates virus-induced apoptosis independently of interferon response.West Nile virus: A re-emerging pathogen revisited.Increased pathogenicity of West Nile virus (WNV) by glycosylation of envelope protein and seroprevalence of WNV in wild birds in Far Eastern Russia.Replication cycle and molecular biology of the West Nile virus.
P2860
Q23302003-A0C2ECFA-B05D-45DB-A215-556961CC3E47Q24700044-B0C87604-2BE7-4848-BAD8-67F40C9FBAE0Q26314693-F63C5AC9-B7F8-4B74-891C-9AD58DA7F4D6Q26796199-5D234225-B59E-4063-AA06-6182A97B41B5Q26999702-FCCD7A2A-47D5-4C3C-89F1-BEE43A93BE6AQ27025556-77A95727-2E27-4153-93D0-59B00D37323CQ27321020-555583FF-1007-4F99-832E-C5D58078CE61Q27480366-E5E94E6E-BFC3-48B4-BD82-527B1AC6C2BBQ27480939-FFB36EF7-CF1A-48DE-B0AA-8F9067DF66ADQ27481490-37D03350-5FAE-4575-95B5-DAFF8A660F84Q27484997-71DDCCB3-BD56-49C3-816A-D2FCD3FD9B70Q27485096-8F693C53-F070-4DAE-8C2A-1C35F8DD0B36Q27485580-1AEE4137-7C9C-406D-9F5A-18DE63B4F342Q27487383-5811EEB3-1189-44F0-9938-EB6D2AAB7FE4Q27487475-159CEEB8-915A-4B14-ABFD-6AE90583E2A3Q27490847-55C32256-8E6C-4B5B-BB09-5533731A4603Q27491308-CC614C35-F80F-482A-8F8F-06E28C66483FQ28534723-C9880234-EB3E-4EDA-99FD-DADFE9292ED2Q28538841-6BB5F0F1-7AD1-4456-8FBF-D0A28DEC06AAQ34035068-0A0ED65E-18C3-4CAA-8417-7EBB1237964CQ34218526-CA578972-CA9F-4623-9900-F164D635C879Q34460502-9F4C31EE-3984-42A8-BD37-012307574162Q34580911-6E88608F-3156-4AA4-80B0-EAEAA4EA9402Q34788758-E848C816-B5BE-490A-9A35-58810E9D7273Q34949783-B1D18F90-E468-40B8-9A2B-37BABD98EF3DQ35042669-EC2CF3C7-D40A-44EE-9BA1-7921112A5076Q35075777-990116B3-6370-4AAB-87AE-0AE399DEA40EQ35531676-3D96C1AB-D595-447B-9E30-F80816843B87Q35826344-D27566E0-EA49-47BE-840B-E9F6DB422C5FQ35876730-38E26E9E-8426-4F79-8F9D-978E1E773260Q36093502-029BC842-DD86-4EC1-A4AC-C8B84699EA86Q36226190-69B05565-0539-4B49-A549-05F2A9815BB9Q36235097-230391ED-0E6E-4296-9E8A-C04EC96642FDQ36645530-08B5B2B4-96A5-4BDC-B172-16592921C902Q36921315-34809101-7E59-4F3F-ACBC-E02A3B2D6761Q36978578-D38D9FC8-497E-4FBB-89A0-04B056CC24A9Q37006746-D8F500C4-D74A-4693-8B54-CC25B80FEE7DQ37195527-55243136-767F-4C4B-A384-80BCD72DA45AQ37434923-E53CA44D-7F42-41DE-B308-26D255D1B482Q37566687-016BDD89-9215-4133-8E68-258713AE69BD
P2860
A single amino acid substitution in the central portion of the West Nile virus NS4B protein confers a highly attenuated phenotype in mice.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
A single amino acid substituti ...... attenuated phenotype in mice.
@en
type
label
A single amino acid substituti ...... attenuated phenotype in mice.
@en
prefLabel
A single amino acid substituti ...... attenuated phenotype in mice.
@en
P2093
P50
P1433
P1476
A single amino acid substituti ...... attenuated phenotype in mice.
@en
P2093
C Todd Davis
Jason A Wicker
Melissa C Whiteman
Richard M Kinney
Shuliu Zhang
P304
P356
10.1016/J.VIROL.2006.03.007
P407
P577
2006-04-19T00:00:00Z