Asp177 in C4 domain of mouse sphingosine kinase 1a is important for the sphingosine recognition.
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Sphingosine kinase-1 is cleaved by cathepsin B in vitro: identification of the initial cleavage sites for the proteaseThe compartmentalization and translocation of the sphingosine kinases: mechanisms and functions in cell signaling and sphingolipid metabolismBiological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agentStructure-activity relationship studies and in vivo activity of guanidine-based sphingosine kinase inhibitors: discovery of SphK1- and SphK2-selective inhibitors.Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors.Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitorsSphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation.FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells.Maternal and Zygotic Sphingosine Kinase 2 Are Indispensable for Cardiac Development in Zebrafish.The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function.Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: review of sphingosine kinase inhibitors.Signaling at the membrane interface by the DGK/SK enzyme familyInvolvement of sphingosine kinase in plant cell signallingSphingosine-1-phosphate metabolism: A structural perspective.Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism.Enhancement of sphingosine kinase 1 catalytic activity by deletion of 21 amino acids from the COOH-terminus."Dicing and Splicing" Sphingosine Kinase and Relevance to Cancer.Crystal Structure of Sphingosine Kinase 1 with PF-543The leucine 10 residue in the pleckstrin homology domain of ceramide kinase is crucial for its catalytic activity.The calmodulin-binding site of sphingosine kinase and its role in agonist-dependent translocation of sphingosine kinase 1 to the plasma membrane.
P2860
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P2860
Asp177 in C4 domain of mouse sphingosine kinase 1a is important for the sphingosine recognition.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Asp177 in C4 domain of mouse s ...... r the sphingosine recognition.
@en
type
label
Asp177 in C4 domain of mouse s ...... r the sphingosine recognition.
@en
prefLabel
Asp177 in C4 domain of mouse s ...... r the sphingosine recognition.
@en
P2093
P2860
P1433
P1476
Asp177 in C4 domain of mouse s ...... r the sphingosine recognition.
@en
P2093
Akio Kihara
Shinji Yokota
Susumu Mitsutake
Yasuyuki Igarashi
Yuki Taniguchi
P2860
P304
P356
10.1016/J.FEBSLET.2004.10.081
P407
P577
2004-12-01T00:00:00Z